Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2807927..2808452 Replicon chromosome
Accession NZ_CP053189
Organism Streptomyces sp. jing01

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HKX69_RS12060 Protein ID WP_171153185.1
Coordinates 2808189..2808452 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HKX69_RS12055 Protein ID WP_171153183.1
Coordinates 2807927..2808196 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKX69_RS12035 2803347..2804564 + 1218 WP_171153175.1 proteinase inhibitor I4 serpin -
HKX69_RS12040 2805163..2805999 - 837 WP_171153178.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
HKX69_RS12045 2806220..2806492 + 273 WP_171153180.1 hypothetical protein -
HKX69_RS12050 2806526..2807479 - 954 WP_171153181.1 hypothetical protein -
HKX69_RS12055 2807927..2808196 + 270 WP_171153183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HKX69_RS12060 2808189..2808452 + 264 WP_171153185.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKX69_RS12065 2808586..2809674 - 1089 WP_171153187.1 redox-regulated ATPase YchF -
HKX69_RS12070 2809860..2810501 + 642 WP_171153188.1 hypothetical protein -
HKX69_RS12075 2810535..2811281 - 747 WP_171153190.1 ROK family protein -
HKX69_RS12080 2811311..2812327 - 1017 WP_171153191.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10056.49 Da        Isoelectric Point: 8.5041

>T156221 WP_171153185.1 NZ_CP053189:2808189-2808452 [Streptomyces sp. jing01]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTELESDPLGFNTTALVSQPDRRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTVYDT

Download         Length: 264 bp

>T156221 NZ_CP068983:c2488030-2487776 [Paradevosia shaoguanensis]
GTGAAGCTCACCTTCTCCGATGACGGCTGGGAGGATTATCTGCACTGGCAGGCGCAGGACAAGAAGCTGCTGAAGCGGCT
CAATGCCTTGATCAAGGAATGCCAGCGGACCCCATTTTCAGGCACAGGCAAACCGGAGCCTCTAAAGGGGGAATTGTCCG
GATACTGGTCGCGCCGCCTCGATCAGGAGCATCGGCTCGTTTACCGCTACGCTGAAGACGCGCTCGAAATAGTCCAGTGC
CGTAAACACTACTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10289.78 Da        Isoelectric Point: 4.7777

>AT156221 WP_171153183.1 NZ_CP053189:2807927-2808196 [Streptomyces sp. jing01]
MTKPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARSE

Download         Length: 270 bp

>AT156221 NZ_CP068983:c2488281-2488027 [Paradevosia shaoguanensis]
ATGCGCACGAAATCCATTTCCGACTTCCGCAAGAACATTGCCGAGGACATCAACGATGTCGTCGAGGACCATGTGCCGCT
CCTCATCACCCGCGGCGGCGGCAAGCCCGCAGCCGTGGTGATGTCGCTTGAGGACTTTGCCTCGTGGCAGGAGACGAACT
ACCTGCTTGGCAGCCCCAAGAATGCCAAGCGTCTCCTGCGCTCGATCAGGCAGCTGGAAGAAGGCAAGGCGACGGAGCGG
AAGCTCATAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References