Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
| Location | 2689123..2690231 | Replicon | chromosome |
| Accession | NZ_CP053185 | ||
| Organism | Staphylococcus aureus strain Guangzhou-SAU749 | ||
Toxin (Protein)
| Gene name | MNTss | Uniprot ID | R3JIN1 |
| Locus tag | HLG72_RS13395 | Protein ID | WP_000233000.1 |
| Coordinates | 2689123..2689992 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | Xress | Uniprot ID | - |
| Locus tag | HLG72_RS13400 | Protein ID | WP_000205227.1 |
| Coordinates | 2690007..2690231 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HLG72_RS13360 | 2684616..2685353 | - | 738 | WP_001038790.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| HLG72_RS13365 | 2685478..2685561 | - | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| HLG72_RS13375 | 2686103..2686897 | - | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
| HLG72_RS13380 | 2686990..2687470 | - | 481 | Protein_2591 | GNAT family N-acetyltransferase | - |
| HLG72_RS13385 | 2687467..2688375 | - | 909 | WP_001255866.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
| HLG72_RS13390 | 2688408..2689142 | - | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
| HLG72_RS13395 | 2689123..2689992 | - | 870 | WP_000233000.1 | nucleotidyltransferase domain-containing protein | Toxin |
| HLG72_RS13400 | 2690007..2690231 | - | 225 | WP_000205227.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HLG72_RS13405 | 2690374..2691918 | - | 1545 | WP_002390960.1 | recombinase family protein | - |
| HLG72_RS13410 | 2691938..2692354 | - | 417 | WP_000323438.1 | recombinase | - |
| HLG72_RS13415 | 2692355..2692651 | - | 297 | WP_002360685.1 | hypothetical protein | - |
| HLG72_RS13420 | 2693163..2693840 | - | 678 | Protein_2599 | DNA topoisomerase III | - |
| HLG72_RS13425 | 2693856..2694458 | - | 603 | WP_001062586.1 | recombinase family protein | - |
| HLG72_RS13430 | 2694472..2694642 | - | 171 | WP_000713595.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | erm(B) / aph(3')-III / ant(6)-Ia | - | 2684480..2697066 | 12586 | |
| - | flank | IS/Tn | erm(B) / aph(3')-III / ant(6)-Ia | - | 2679700..2688375 | 8675 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32926.57 Da Isoelectric Point: 4.8781
>T156220 WP_000233000.1 NZ_CP053185:c2689992-2689123 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
>T156220 NZ_CP068983:c2471926-2471678 [Paradevosia shaoguanensis]
ATGCTGATCAGCTACGACGAAGCCAAGCGCCTCACCAACCTGGCTAAACACGGCTTGGACTTCGAAGCGCTCACCGTCGA
GTTCTTCGAGGCTGCGGTTATCTTCCCAGCCAAGGTAGGTCGCGCACTCGCCATCGGTGAACTGAATGGCCAGATCGTCA
TTGCCGTGGTGTTCCGCCCGCTGGGTTCGGAGGCACTGTCCGTGATTTCGATGCGCCCCGCCAGCCGAAAGGAAAGGAAG
CTTTTATGA
ATGCTGATCAGCTACGACGAAGCCAAGCGCCTCACCAACCTGGCTAAACACGGCTTGGACTTCGAAGCGCTCACCGTCGA
GTTCTTCGAGGCTGCGGTTATCTTCCCAGCCAAGGTAGGTCGCGCACTCGCCATCGGTGAACTGAATGGCCAGATCGTCA
TTGCCGTGGTGTTCCGCCCGCTGGGTTCGGAGGCACTGTCCGTGATTTCGATGCGCCCCGCCAGCCGAAAGGAAAGGAAG
CTTTTATGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8365.68 Da Isoelectric Point: 4.5510
>AT156220 WP_000205227.1 NZ_CP053185:c2690231-2690007 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE
Download Length: 225 bp
>AT156220 NZ_CP068983:c2471681-2471361 [Paradevosia shaoguanensis]
ATGACCAAGAAATTTGCCTCGGGGCGCCCGCTTACAGATGCCGAGGAGGCCGAGATCCAACGCATGATCGCGTCGGACCC
GGACAATCCTGAACTCACTGACGAGCAGATTGCCGCCGGTGGCAAGCCGTTTGCCGAGGTCTTCCCGGAATTGGCCGAAA
GCATCAAGCGCAGCCGGGGGCGCCCGAAGCTTTCCAACGCCAAGCAGGCGGTAACCCTGCGCCTTGACCCGTCGACGCTG
GCCAAGTTCCAGGCCGCCGGCGACGACTGGCGCACCCGCATGGCCGAAGTGCTGGACAAAGCGAAGGTAGGTGGCCGCTA
G
ATGACCAAGAAATTTGCCTCGGGGCGCCCGCTTACAGATGCCGAGGAGGCCGAGATCCAACGCATGATCGCGTCGGACCC
GGACAATCCTGAACTCACTGACGAGCAGATTGCCGCCGGTGGCAAGCCGTTTGCCGAGGTCTTCCCGGAATTGGCCGAAA
GCATCAAGCGCAGCCGGGGGCGCCCGAAGCTTTCCAACGCCAAGCAGGCGGTAACCCTGCGCCTTGACCCGTCGACGCTG
GCCAAGTTCCAGGCCGCCGGCGACGACTGGCGCACCCGCATGGCCGAAGTGCTGGACAAAGCGAAGGTAGGTGGCCGCTA
G
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|