Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2144120..2144634 Replicon chromosome
Accession NZ_CP053185
Organism Staphylococcus aureus strain Guangzhou-SAU749

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HLG72_RS10635 Protein ID WP_000581792.1
Coordinates 2144120..2144329 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag HLG72_RS10640 Protein ID WP_000138934.1
Coordinates 2144341..2144634 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLG72_RS10615 2139628..2140986 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
HLG72_RS10620 2141001..2142071 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
HLG72_RS10625 2142389..2143591 + 1203 WP_001109939.1 rod shape-determining protein RodA -
HLG72_RS10630 2143855..2143992 - 138 WP_000828354.1 hypothetical protein -
HLG72_RS10635 2144120..2144329 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HLG72_RS10640 2144341..2144634 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
HLG72_RS10645 2144800..2146284 + 1485 WP_000571549.1 cardiolipin synthase -
HLG72_RS10650 2146312..2146959 + 648 WP_001187610.1 HD domain-containing protein -
HLG72_RS10655 2147774..2148646 - 873 WP_000725802.1 membrane protein insertase YidC -
HLG72_RS10660 2148732..2149373 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T156214 WP_000581792.1 NZ_CP053185:c2144329-2144120 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T156214 NZ_CP068982:516903-517253 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT156214 WP_000138934.1 NZ_CP053185:c2144634-2144341 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT156214 NZ_CP068982:516617-516898 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References