Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1943278..1944075 Replicon chromosome
Accession NZ_CP053185
Organism Staphylococcus aureus strain Guangzhou-SAU749

Toxin (Protein)


Gene name - Uniprot ID A0A6B0C7N0
Locus tag HLG72_RS09500 Protein ID WP_000525009.1
Coordinates 1943614..1944075 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag HLG72_RS09495 Protein ID WP_001260487.1
Coordinates 1943278..1943601 (+) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLG72_RS09435 1938575..1939018 - 444 WP_103694883.1 single-stranded DNA-binding protein -
HLG72_RS09440 1939015..1939665 - 651 WP_000840496.1 ERF family protein -
HLG72_RS09445 1939666..1940202 - 537 WP_001004336.1 host-nuclease inhibitor Gam family protein -
HLG72_RS09450 1940215..1940475 - 261 WP_001556704.1 DUF1108 family protein -
HLG72_RS09455 1940480..1940797 - 318 WP_000829613.1 hypothetical protein -
HLG72_RS09460 1940886..1941047 - 162 WP_000048124.1 DUF1270 family protein -
HLG72_RS09465 1941061..1941270 - 210 WP_000455727.1 hypothetical protein -
HLG72_RS09470 1941283..1941996 - 714 WP_031925041.1 ORF6C domain-containing protein -
HLG72_RS09475 1942053..1942262 + 210 WP_000772137.1 hypothetical protein -
HLG72_RS09480 1942255..1942395 - 141 WP_000939495.1 hypothetical protein -
HLG72_RS09485 1942410..1942853 - 444 WP_000435360.1 hypothetical protein -
HLG72_RS09490 1942866..1943114 - 249 WP_000272859.1 helix-turn-helix domain-containing protein -
HLG72_RS09495 1943278..1943601 + 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
HLG72_RS09500 1943614..1944075 + 462 WP_000525009.1 hypothetical protein Toxin
HLG72_RS09505 1944093..1944608 + 516 WP_170833572.1 hypothetical protein -
HLG72_RS09510 1944670..1945719 + 1050 WP_000146088.1 site-specific integrase -
HLG72_RS09555 1946997..1947551 - 555 WP_000132890.1 alpha/beta hydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp 1893472..1947551 54079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(8-65)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 18060.39 Da        Isoelectric Point: 4.5941

>T156211 WP_000525009.1 NZ_CP053185:1943614-1944075 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T156211 NZ_CP068972:c4664110-4663826 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT156211 WP_001260487.1 NZ_CP053185:1943278-1943601 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT156211 NZ_CP068972:c4664342-4664100 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A6B0C7N0


Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References