Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
Location | 1943278..1944075 | Replicon | chromosome |
Accession | NZ_CP053185 | ||
Organism | Staphylococcus aureus strain Guangzhou-SAU749 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A6B0C7N0 |
Locus tag | HLG72_RS09500 | Protein ID | WP_000525009.1 |
Coordinates | 1943614..1944075 (+) | Length | 154 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A0C2LD36 |
Locus tag | HLG72_RS09495 | Protein ID | WP_001260487.1 |
Coordinates | 1943278..1943601 (+) | Length | 108 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HLG72_RS09435 | 1938575..1939018 | - | 444 | WP_103694883.1 | single-stranded DNA-binding protein | - |
HLG72_RS09440 | 1939015..1939665 | - | 651 | WP_000840496.1 | ERF family protein | - |
HLG72_RS09445 | 1939666..1940202 | - | 537 | WP_001004336.1 | host-nuclease inhibitor Gam family protein | - |
HLG72_RS09450 | 1940215..1940475 | - | 261 | WP_001556704.1 | DUF1108 family protein | - |
HLG72_RS09455 | 1940480..1940797 | - | 318 | WP_000829613.1 | hypothetical protein | - |
HLG72_RS09460 | 1940886..1941047 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
HLG72_RS09465 | 1941061..1941270 | - | 210 | WP_000455727.1 | hypothetical protein | - |
HLG72_RS09470 | 1941283..1941996 | - | 714 | WP_031925041.1 | ORF6C domain-containing protein | - |
HLG72_RS09475 | 1942053..1942262 | + | 210 | WP_000772137.1 | hypothetical protein | - |
HLG72_RS09480 | 1942255..1942395 | - | 141 | WP_000939495.1 | hypothetical protein | - |
HLG72_RS09485 | 1942410..1942853 | - | 444 | WP_000435360.1 | hypothetical protein | - |
HLG72_RS09490 | 1942866..1943114 | - | 249 | WP_000272859.1 | helix-turn-helix domain-containing protein | - |
HLG72_RS09495 | 1943278..1943601 | + | 324 | WP_001260487.1 | helix-turn-helix domain-containing protein | Antitoxin |
HLG72_RS09500 | 1943614..1944075 | + | 462 | WP_000525009.1 | hypothetical protein | Toxin |
HLG72_RS09505 | 1944093..1944608 | + | 516 | WP_170833572.1 | hypothetical protein | - |
HLG72_RS09510 | 1944670..1945719 | + | 1050 | WP_000146088.1 | site-specific integrase | - |
HLG72_RS09555 | 1946997..1947551 | - | 555 | WP_000132890.1 | alpha/beta hydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | scn / chp | 1893472..1947551 | 54079 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18060.39 Da Isoelectric Point: 4.5941
>T156211 WP_000525009.1 NZ_CP053185:1943614-1944075 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T156211 NZ_CP068972:c4664110-4663826 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT156211 WP_001260487.1 NZ_CP053185:1943278-1943601 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT156211 NZ_CP068972:c4664342-4664100 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6B0C7N0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0C2LD36 |