Detailed information of TA system TA156211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1943278..1944075
• Replicon: chromosome
• Accession: NZ_CP053185
• Organism: Staphylococcus aureus strain Guangzhou-SAU749

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A6B0C7N0
• Locus tag: HLG72_RS09500
• Protein ID: WP_000525009.1
• Coordinates: 1943614..1944075 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: HLG72_RS09495
• Protein ID: WP_001260487.1
• Coordinates: 1943278..1943601 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLG72_RS09435	1938575..1939018	-	444	WP_103694883.1	single-stranded DNA-binding protein	-
HLG72_RS09440	1939015..1939665	-	651	WP_000840496.1	ERF family protein	-
HLG72_RS09445	1939666..1940202	-	537	WP_001004336.1	host-nuclease inhibitor Gam family protein	-
HLG72_RS09450	1940215..1940475	-	261	WP_001556704.1	DUF1108 family protein	-
HLG72_RS09455	1940480..1940797	-	318	WP_000829613.1	hypothetical protein	-
HLG72_RS09460	1940886..1941047	-	162	WP_000048124.1	DUF1270 family protein	-
HLG72_RS09465	1941061..1941270	-	210	WP_000455727.1	hypothetical protein	-
HLG72_RS09470	1941283..1941996	-	714	WP_031925041.1	ORF6C domain-containing protein	-
HLG72_RS09475	1942053..1942262	+	210	WP_000772137.1	hypothetical protein	-
HLG72_RS09480	1942255..1942395	-	141	WP_000939495.1	hypothetical protein	-
HLG72_RS09485	1942410..1942853	-	444	WP_000435360.1	hypothetical protein	-
HLG72_RS09490	1942866..1943114	-	249	WP_000272859.1	helix-turn-helix domain-containing protein	-
HLG72_RS09495	1943278..1943601	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
HLG72_RS09500	1943614..1944075	+	462	WP_000525009.1	hypothetical protein	Toxin
HLG72_RS09505	1944093..1944608	+	516	WP_170833572.1	hypothetical protein	-
HLG72_RS09510	1944670..1945719	+	1050	WP_000146088.1	site-specific integrase	-
HLG72_RS09555	1946997..1947551	-	555	WP_000132890.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp	1893472..1947551	54079

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18060.39 Da
• Isoelectric Point: 4.5941

>T156211 WP_000525009.1 NZ_CP053185:1943614-1944075 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T156211 NZ_CP068972:c4664110-4663826 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT156211 WP_001260487.1 NZ_CP053185:1943278-1943601 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT156211 NZ_CP068972:c4664342-4664100 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A6B0C7N0

Antitoxin

• AlphaFold DB: A0A0C2LD36