Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 902970..903502 | Replicon | chromosome |
| Accession | NZ_CP053185 | ||
| Organism | Staphylococcus aureus strain Guangzhou-SAU749 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | Q93CD4 |
| Locus tag | HLG72_RS04455 | Protein ID | WP_001103942.1 |
| Coordinates | 903182..903502 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | HLG72_RS04450 | Protein ID | WP_001058486.1 |
| Coordinates | 902970..903179 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HLG72_RS04405 | 897989..899209 | - | 1221 | WP_000266157.1 | site-specific integrase | - |
| HLG72_RS04410 | 899298..900026 | - | 729 | WP_000733774.1 | staphylococcal enterotoxin type K | - |
| HLG72_RS04415 | 900050..900778 | - | 729 | WP_001033318.1 | staphylococcal enterotoxin type Q | - |
| HLG72_RS04420 | 900848..901279 | - | 432 | WP_001228759.1 | hypothetical protein | - |
| HLG72_RS04425 | 901296..901754 | - | 459 | WP_000281657.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HLG72_RS04430 | 901766..902098 | - | 333 | WP_001260004.1 | helix-turn-helix transcriptional regulator | - |
| HLG72_RS04435 | 902291..902554 | + | 264 | WP_000243851.1 | helix-turn-helix domain-containing protein | - |
| HLG72_RS04440 | 902547..902819 | + | 273 | WP_000091731.1 | helix-turn-helix domain-containing protein | - |
| HLG72_RS04445 | 902831..902977 | + | 147 | WP_000784875.1 | hypothetical protein | - |
| HLG72_RS04450 | 902970..903179 | + | 210 | WP_001058486.1 | hypothetical protein | Antitoxin |
| HLG72_RS04455 | 903182..903502 | + | 321 | WP_001103942.1 | DUF1474 family protein | Toxin |
| HLG72_RS04460 | 903566..904435 | + | 870 | WP_001002732.1 | primase alpha helix C-terminal domain-containing protein | - |
| HLG72_RS04465 | 904452..905921 | + | 1470 | WP_000390454.1 | virulence-associated E family protein | - |
| HLG72_RS04470 | 906207..906569 | + | 363 | WP_001039168.1 | hypothetical protein | - |
| HLG72_RS04475 | 906571..906855 | + | 285 | WP_000998181.1 | hypothetical protein | - |
| HLG72_RS04480 | 906852..907493 | + | 642 | WP_001019764.1 | hypothetical protein | - |
| HLG72_RS04485 | 908010..908351 | + | 342 | WP_001190615.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selk / selq / seb | 892553..913302 | 20749 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12694.22 Da Isoelectric Point: 4.7419
>T156210 WP_001103942.1 NZ_CP053185:903182-903502 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
Download Length: 321 bp
>T156210 NZ_CP068972:c4554892-4554359 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8252.31 Da Isoelectric Point: 4.3718
>AT156210 WP_001058486.1 NZ_CP053185:902970-903179 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT156210 NZ_CP068972:c4555169-4554903 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|