Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 885274..885751 Replicon chromosome
Accession NZ_CP053185
Organism Staphylococcus aureus strain Guangzhou-SAU749

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HLG72_RS04310 Protein ID WP_000052076.1
Coordinates 885274..885462 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HLG72_RS04315 Protein ID WP_001059690.1
Coordinates 885491..885751 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLG72_RS04280 881312..881782 + 471 WP_000824462.1 hypothetical protein -
HLG72_RS04285 882123..882809 + 687 WP_001823812.1 thermonuclease family protein -
HLG72_RS04290 883166..883366 + 201 WP_001059082.1 cold-shock protein -
HLG72_RS04295 883865..884083 - 219 WP_000005888.1 hypothetical protein -
HLG72_RS04300 884145..884429 - 285 WP_001004397.1 hypothetical protein -
HLG72_RS04305 884517..885086 - 570 WP_001106657.1 hypothetical protein -
HLG72_RS04310 885274..885462 - 189 WP_000052076.1 hypothetical protein Toxin
HLG72_RS04315 885491..885751 - 261 WP_001059690.1 hypothetical protein Antitoxin
HLG72_RS04320 886092..886295 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HLG72_RS04325 886292..886528 - 237 WP_000368687.1 hypothetical protein -
HLG72_RS04330 886753..887334 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
HLG72_RS04335 887407..888024 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
HLG72_RS04340 888180..888674 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
HLG72_RS04345 889073..889495 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
HLG72_RS04350 889643..890359 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T156209 WP_000052076.1 NZ_CP053185:c885462-885274 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T156209 NZ_CP068972:3958728-3958946 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT156209 WP_001059690.1 NZ_CP053185:c885751-885491 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT156209 NZ_CP068972:3958327-3958701 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References