Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 885274..885751 | Replicon | chromosome |
Accession | NZ_CP053185 | ||
Organism | Staphylococcus aureus strain Guangzhou-SAU749 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | HLG72_RS04310 | Protein ID | WP_000052076.1 |
Coordinates | 885274..885462 (-) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | HLG72_RS04315 | Protein ID | WP_001059690.1 |
Coordinates | 885491..885751 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HLG72_RS04280 | 881312..881782 | + | 471 | WP_000824462.1 | hypothetical protein | - |
HLG72_RS04285 | 882123..882809 | + | 687 | WP_001823812.1 | thermonuclease family protein | - |
HLG72_RS04290 | 883166..883366 | + | 201 | WP_001059082.1 | cold-shock protein | - |
HLG72_RS04295 | 883865..884083 | - | 219 | WP_000005888.1 | hypothetical protein | - |
HLG72_RS04300 | 884145..884429 | - | 285 | WP_001004397.1 | hypothetical protein | - |
HLG72_RS04305 | 884517..885086 | - | 570 | WP_001106657.1 | hypothetical protein | - |
HLG72_RS04310 | 885274..885462 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
HLG72_RS04315 | 885491..885751 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
HLG72_RS04320 | 886092..886295 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
HLG72_RS04325 | 886292..886528 | - | 237 | WP_000368687.1 | hypothetical protein | - |
HLG72_RS04330 | 886753..887334 | + | 582 | WP_001140697.1 | phosphoglycerate mutase family protein | - |
HLG72_RS04335 | 887407..888024 | - | 618 | WP_000255554.1 | LysE/ArgO family amino acid transporter | - |
HLG72_RS04340 | 888180..888674 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
HLG72_RS04345 | 889073..889495 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
HLG72_RS04350 | 889643..890359 | + | 717 | WP_000150029.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T156209 WP_000052076.1 NZ_CP053185:c885462-885274 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T156209 NZ_CP068972:3958728-3958946 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT156209 WP_001059690.1 NZ_CP053185:c885751-885491 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT156209 NZ_CP068972:3958327-3958701 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |