Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2101890..2102404 Replicon chromosome
Accession NZ_CP053183
Organism Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HLB24_RS10275 Protein ID WP_000581792.1
Coordinates 2101890..2102099 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag HLB24_RS10280 Protein ID WP_000138934.1
Coordinates 2102111..2102404 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB24_RS10255 2097398..2098756 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
HLB24_RS10260 2098771..2099841 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
HLB24_RS10265 2100159..2101361 + 1203 WP_001109939.1 rod shape-determining protein RodA -
HLB24_RS10270 2101625..2101762 - 138 WP_000828354.1 hypothetical protein -
HLB24_RS10275 2101890..2102099 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HLB24_RS10280 2102111..2102404 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
HLB24_RS10285 2102570..2104054 + 1485 WP_057504585.1 cardiolipin synthase -
HLB24_RS10290 2104082..2104729 + 648 WP_001187610.1 HD domain-containing protein -
HLB24_RS10295 2105544..2106416 - 873 WP_000725802.1 membrane protein insertase YidC -
HLB24_RS10300 2106502..2107143 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T156199 WP_000581792.1 NZ_CP053183:c2102099-2101890 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T156199 NZ_CP068830:c4605905-4605555 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT156199 WP_000138934.1 NZ_CP053183:c2102404-2102111 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT156199 NZ_CP068830:c4606150-4605899 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References