Detailed information of TA system TA156198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2082150..2082679
• Replicon: chromosome
• Accession: NZ_CP053183
• Organism: Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HLB24_RS10185
• Protein ID: WP_000621175.1
• Coordinates: 2082150..2082512 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: HLB24_RS10190
• Protein ID: WP_000948331.1
• Coordinates: 2082509..2082679 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB24_RS10165	2079129..2079899	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
HLB24_RS10170	2079874..2080353	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
HLB24_RS10175	2080355..2080681	-	327	WP_001052491.1	anti-sigma factor antagonist	-
HLB24_RS10180	2080800..2081801	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
HLB24_RS10185	2082150..2082512	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HLB24_RS10190	2082509..2082679	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HLB24_RS10195	2082764..2083912	-	1149	WP_001280702.1	alanine racemase	-
HLB24_RS10200	2083978..2084337	-	360	WP_000581194.1	holo-ACP synthase	-
HLB24_RS10205	2084341..2084832	-	492	WP_001205915.1	PH domain-containing protein	-
HLB24_RS10210	2084819..2086402	-	1584	WP_001294642.1	PH domain-containing protein	-
HLB24_RS10215	2086395..2086874	-	480	WP_001287083.1	hypothetical protein	-
HLB24_RS10220	2087083..2087643	-	561	WP_001092405.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T156198 WP_000621175.1 NZ_CP053183:c2082512-2082150 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T156198 NZ_CP068830:c4594183-4593893 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT156198 WP_000948331.1 NZ_CP053183:c2082679-2082509 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT156198 NZ_CP068830:c4594415-4594173 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1