Detailed information of TA system TA156193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 856934..857466
• Replicon: chromosome
• Accession: NZ_CP053183
• Organism: Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: HLB24_RS04060
• Protein ID: WP_001103942.1
• Coordinates: 857146..857466 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: HLB24_RS04055
• Protein ID: WP_001058486.1
• Coordinates: 856934..857143 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB24_RS04010	851952..853172	-	1221	WP_000266157.1	site-specific integrase	-
HLB24_RS04015	853261..853989	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
HLB24_RS04020	854013..854741	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
HLB24_RS04025	854812..855243	-	432	WP_001228759.1	hypothetical protein	-
HLB24_RS04030	855260..855718	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
HLB24_RS04035	855730..856062	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
HLB24_RS04040	856255..856518	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
HLB24_RS04045	856511..856783	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
HLB24_RS04050	856795..856941	+	147	WP_000784875.1	hypothetical protein	-
HLB24_RS04055	856934..857143	+	210	WP_001058486.1	hypothetical protein	Antitoxin
HLB24_RS04060	857146..857466	+	321	WP_001103942.1	DUF1474 family protein	Toxin
HLB24_RS04065	857530..858401	+	872	Protein_788	primase alpha helix C-terminal domain-containing protein	-
HLB24_RS04070	858418..859887	+	1470	WP_000390454.1	virulence-associated E family protein	-
HLB24_RS04075	860173..860535	+	363	WP_001039168.1	hypothetical protein	-
HLB24_RS04080	860537..860821	+	285	WP_000998181.1	hypothetical protein	-
HLB24_RS04085	860818..861459	+	642	WP_001019764.1	hypothetical protein	-
HLB24_RS04090	861976..862317	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	833917..867268	33351

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T156193 WP_001103942.1 NZ_CP053183:857146-857466 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T156193 NZ_CP068830:3862466-3862684 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT156193 WP_001058486.1 NZ_CP053183:856934-857143 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT156193 NZ_CP068830:3862066-3862440 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: Q93CD4