Detailed information of TA system TA156192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 839237..839714
• Replicon: chromosome
• Accession: NZ_CP053183
• Organism: Staphylococcus aureus strain Guangzhou-SAU071

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: HLB24_RS03915
• Protein ID: WP_000052076.1
• Coordinates: 839237..839425 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: HLB24_RS03920
• Protein ID: WP_001059690.1
• Coordinates: 839454..839714 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB24_RS03885	835275..835745	+	471	WP_000824462.1	hypothetical protein	-
HLB24_RS03890	836086..836772	+	687	WP_001823812.1	thermonuclease family protein	-
HLB24_RS03895	837129..837329	+	201	WP_001059082.1	cold-shock protein	-
HLB24_RS03900	837828..838046	-	219	WP_000005888.1	hypothetical protein	-
HLB24_RS03905	838108..838392	-	285	WP_001004397.1	hypothetical protein	-
HLB24_RS03910	838480..839049	-	570	WP_001106657.1	hypothetical protein	-
HLB24_RS03915	839237..839425	-	189	WP_000052076.1	hypothetical protein	Toxin
HLB24_RS03920	839454..839714	-	261	WP_001059690.1	hypothetical protein	Antitoxin
HLB24_RS03925	840055..840258	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
HLB24_RS03930	840255..840491	-	237	WP_000368687.1	hypothetical protein	-
HLB24_RS03935	840716..841297	+	582	WP_001140697.1	phosphoglycerate mutase family protein	-
HLB24_RS03940	841370..841987	-	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-
HLB24_RS03945	842143..842637	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
HLB24_RS03950	843036..843458	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
HLB24_RS03955	843606..844322	+	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	833917..867268	33351

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T156192 WP_000052076.1 NZ_CP053183:c839425-839237 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T156192 NZ_CP068830:3408307-3408693 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT156192 WP_001059690.1 NZ_CP053183:c839714-839454 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT156192 NZ_CP068830:3408683-3409012 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56