Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 1766571..1767265 | Replicon | chromosome |
| Accession | NZ_CP053181 | ||
| Organism | Enterococcus faecalis strain FMAMOB6 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | - |
| Locus tag | HLJ13_RS08705 | Protein ID | WP_105194759.1 |
| Coordinates | 1766921..1767265 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | HLJ13_RS08700 | Protein ID | WP_002364355.1 |
| Coordinates | 1766571..1766903 (+) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HLJ13_RS08650 (1761689) | 1761689..1761889 | - | 201 | WP_057086713.1 | hypothetical protein | - |
| HLJ13_RS08655 (1761886) | 1761886..1762029 | - | 144 | WP_226088781.1 | hypothetical protein | - |
| HLJ13_RS08660 (1762098) | 1762098..1763009 | - | 912 | WP_105194763.1 | YqaJ viral recombinase family protein | - |
| HLJ13_RS08665 (1763022) | 1763022..1763264 | - | 243 | WP_010826713.1 | hypothetical protein | - |
| HLJ13_RS08670 (1763266) | 1763266..1764462 | - | 1197 | WP_016626781.1 | DEAD/DEAH box helicase | - |
| HLJ13_RS08675 (1764452) | 1764452..1764745 | - | 294 | WP_010826715.1 | VRR-NUC domain-containing protein | - |
| HLJ13_RS08680 (1764742) | 1764742..1764942 | - | 201 | WP_105194762.1 | hypothetical protein | - |
| HLJ13_RS08685 (1765157) | 1765157..1765456 | - | 300 | WP_248881988.1 | hypothetical protein | - |
| HLJ13_RS08690 (1765761) | 1765761..1766072 | - | 312 | WP_105194760.1 | hypothetical protein | - |
| HLJ13_RS08695 (1766083) | 1766083..1766259 | - | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| HLJ13_RS08700 (1766571) | 1766571..1766903 | + | 333 | WP_002364355.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HLJ13_RS08705 (1766921) | 1766921..1767265 | + | 345 | WP_105194759.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| HLJ13_RS08710 (1767299) | 1767299..1768028 | + | 730 | Protein_1689 | potassium channel family protein | - |
| HLJ13_RS08715 (1768125) | 1768125..1769273 | + | 1149 | WP_105194837.1 | site-specific integrase | - |
| HLJ13_RS08720 (1769301) | 1769301..1769744 | - | 444 | WP_033918701.1 | competence type IV pilus minor pilin ComGD | - |
| HLJ13_RS08725 (1769741) | 1769741..1770016 | - | 276 | WP_002356991.1 | competence type IV pilus major pilin ComGC | - |
| HLJ13_RS08730 (1770016) | 1770016..1771062 | - | 1047 | WP_002369171.1 | competence type IV pilus assembly protein ComGB | - |
| HLJ13_RS08735 (1771019) | 1771019..1771987 | - | 969 | WP_002398077.1 | competence type IV pilus ATPase ComGA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1733647..1788123 | 54476 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13707.58 Da Isoelectric Point: 5.5339
>T156167 WP_105194759.1 NZ_CP053181:1766921-1767265 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPSERIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHEGQFNYSNVVTHYNLKMGQETYLK
MKSIKELVEEYEVELVFAPINKRACYEPSERIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHEGQFNYSNVVTHYNLKMGQETYLK
Download Length: 345 bp
>T156167 NZ_CP068829:c4008389-4007991 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT156167 WP_002364355.1 NZ_CP053181:1766571-1766903 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT156167 NZ_CP068829:c4008685-4008392 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|