Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 450435..450964 Replicon chromosome
Accession NZ_CP053180
Organism Enterococcus casseliflavus strain SP11

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HLJ12_RS02135 Protein ID WP_081116192.1
Coordinates 450698..450964 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A377KQM1
Locus tag HLJ12_RS02130 Protein ID WP_010748737.1
Coordinates 450435..450698 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLJ12_RS02115 (HLJ12_02110) 446004..447269 - 1266 WP_208773556.1 glycoside hydrolase family 27 protein -
HLJ12_RS02120 (HLJ12_02115) 447390..448289 + 900 WP_081116191.1 AraC family transcriptional regulator -
HLJ12_RS02125 (HLJ12_02120) 448340..450280 + 1941 WP_249850450.1 glycoside hydrolase family 127 protein -
HLJ12_RS02130 (HLJ12_02125) 450435..450698 + 264 WP_010748737.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HLJ12_RS02135 (HLJ12_02130) 450698..450964 + 267 WP_081116192.1 Txe/YoeB family addiction module toxin Toxin
HLJ12_RS02140 (HLJ12_02135) 451300..453987 + 2688 WP_249850451.1 discoidin domain-containing protein -
HLJ12_RS02145 (HLJ12_02140) 454119..454781 - 663 WP_005227316.1 ABC transporter permease -
HLJ12_RS02150 (HLJ12_02145) 454786..455706 - 921 WP_010748740.1 osmoprotectant ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10672.16 Da        Isoelectric Point: 10.0683

>T156161 WP_081116192.1 NZ_CP053180:450698-450964 [Enterococcus casseliflavus]
MRSDTVTIKNSAKVDLRKIKQSNLKKQFEEVIQALKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRMVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T156161 NZ_CP068829:2993273-2993380 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9958.03 Da        Isoelectric Point: 4.2682

>AT156161 WP_010748737.1 NZ_CP053180:450435-450698 [Enterococcus casseliflavus]
MAKTTMNPSTARKNFYQLLKDVNENHTEIEIISDRSGNNAVLIGLGDWRAIQETLFLEQTGTLEKVRDREKDDSGFTDID
DIDWQAL

Download         Length: 264 bp

>AT156161 NZ_CP068829:c2993226-2993160 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A377KQM1

References