Detailed information of TA system TA156156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4671238..4671845
• Replicon: chromosome
• Accession: NZ_CP053103
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain Ec61

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HLA96_RS22300
• Protein ID: WP_160859179.1
• Coordinates: 4671660..4671845 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HLA96_RS22295
• Protein ID: WP_023315016.1
• Coordinates: 4671238..4671645 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLA96_RS22280	4667982..4669235	+	1254	WP_015572749.1	valine--pyruvate transaminase	-
HLA96_RS22285	4669243..4669698	-	456	WP_197620542.1	4Fe-4S dicluster domain-containing protein	-
HLA96_RS22290	4670158..4671234	+	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
HLA96_RS22295	4671238..4671645	-	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HLA96_RS22300	4671660..4671845	-	186	WP_160859179.1	type II toxin-antitoxin system HicA family toxin	Toxin
HLA96_RS22305	4672095..4673633	-	1539	WP_160859177.1	aldehyde dehydrogenase AldB	-
HLA96_RS22310	4673800..4674684	+	885	WP_100397742.1	ROK family protein	-
HLA96_RS22315	4674688..4676526	-	1839	WP_160859175.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6809.05 Da
• Isoelectric Point: 11.2475

>T156156 WP_160859179.1 NZ_CP053103:c4671845-4671660 [Enterobacter hormaechei subsp. xiangfangensis]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWLQAGIKH

Nucleotide

• Length: 186 bp

>T156156 NZ_CP068829:c1121076-1120741 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT156156 WP_023315016.1 NZ_CP053103:c4671645-4671238 [Enterobacter hormaechei subsp. xiangfangensis]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT156156 NZ_CP068829:c1121324-1121076 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA