Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4040270..4041023 | Replicon | chromosome |
| Accession | NZ_CP053103 | ||
| Organism | Enterobacter hormaechei subsp. xiangfangensis strain Ec61 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | R8WN26 |
| Locus tag | HLA96_RS19260 | Protein ID | WP_016154457.1 |
| Coordinates | 4040646..4041023 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | HLA96_RS19255 | Protein ID | WP_162838704.1 |
| Coordinates | 4040270..4040596 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HLA96_RS19195 | 4035328..4035594 | + | 267 | WP_009652486.1 | hypothetical protein | - |
| HLA96_RS19200 | 4035607..4035918 | + | 312 | WP_009652410.1 | hypothetical protein | - |
| HLA96_RS19205 | 4035965..4036435 | + | 471 | WP_009652431.1 | hypothetical protein | - |
| HLA96_RS19210 | 4036484..4036996 | + | 513 | WP_009652395.1 | DUF4234 domain-containing protein | - |
| HLA96_RS19215 | 4037079..4037300 | + | 222 | WP_009652443.1 | hypothetical protein | - |
| HLA96_RS19220 | 4037356..4037589 | + | 234 | WP_009652474.1 | DUF905 domain-containing protein | - |
| HLA96_RS19225 | 4037693..4038511 | + | 819 | WP_009652424.1 | DUF945 domain-containing protein | - |
| HLA96_RS19230 | 4038511..4038765 | + | 255 | WP_009652519.1 | hypothetical protein | - |
| HLA96_RS19235 | 4038794..4039255 | + | 462 | WP_045890390.1 | antirestriction protein | - |
| HLA96_RS19240 | 4039266..4039484 | + | 219 | WP_009652503.1 | hypothetical protein | - |
| HLA96_RS19245 | 4039496..4039978 | + | 483 | WP_016154455.1 | DNA repair protein RadC | - |
| HLA96_RS19250 | 4039992..4040213 | + | 222 | WP_009652392.1 | DUF987 domain-containing protein | - |
| HLA96_RS19255 | 4040270..4040596 | + | 327 | WP_162838704.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HLA96_RS19260 | 4040646..4041023 | + | 378 | WP_016154457.1 | TA system toxin CbtA family protein | Toxin |
| HLA96_RS19265 | 4041020..4041511 | + | 492 | WP_009652438.1 | hypothetical protein | - |
| HLA96_RS19270 | 4041541..4041744 | + | 204 | WP_009652505.1 | DUF957 domain-containing protein | - |
| HLA96_RS19275 | 4041825..4042670 | + | 846 | Protein_3767 | DUF4942 domain-containing protein | - |
| HLA96_RS19280 | 4042988..4044772 | - | 1785 | WP_003862454.1 | hybrid sensor histidine kinase/response regulator | - |
| HLA96_RS19285 | 4044769..4045401 | - | 633 | WP_003862456.1 | response regulator transcription factor | - |
| HLA96_RS19290 | 4045577..4045891 | + | 315 | WP_003862457.1 | lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3904276..4042910 | 138634 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14168.19 Da Isoelectric Point: 9.5224
>T156155 WP_016154457.1 NZ_CP053103:4040646-4041023 [Enterobacter hormaechei subsp. xiangfangensis]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
Download Length: 378 bp
>T156155 NZ_CP068829:978845-979252 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12079.85 Da Isoelectric Point: 6.6283
>AT156155 WP_162838704.1 NZ_CP053103:4040270-4040596 [Enterobacter hormaechei subsp. xiangfangensis]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
Download Length: 327 bp
>AT156155 NZ_CP068829:978598-978864 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|