Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3821913..3822570 Replicon chromosome
Accession NZ_CP053103
Organism Enterobacter hormaechei subsp. xiangfangensis strain Ec61

Toxin (Protein)


Gene name cptA Uniprot ID A0A837FG63
Locus tag HLA96_RS18075 Protein ID WP_003863439.1
Coordinates 3821913..3822323 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HLA96_RS18080 Protein ID WP_003863437.1
Coordinates 3822304..3822570 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLA96_RS18055 3817911..3819644 - 1734 WP_059370853.1 single-stranded-DNA-specific exonuclease RecJ -
HLA96_RS18060 3819650..3820363 - 714 WP_059370854.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HLA96_RS18065 3820392..3821288 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
HLA96_RS18070 3821390..3821911 + 522 WP_003863440.1 flavodoxin FldB -
HLA96_RS18075 3821913..3822323 - 411 WP_003863439.1 protein YgfX Toxin
HLA96_RS18080 3822304..3822570 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HLA96_RS18085 3822865..3823845 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
HLA96_RS18090 3823931..3824590 - 660 WP_003863433.1 hemolysin III family protein -
HLA96_RS18095 3824857..3825588 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
HLA96_RS18100 3825705..3827138 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16339.24 Da        Isoelectric Point: 11.4775

>T156154 WP_003863439.1 NZ_CP053103:c3822323-3821913 [Enterobacter hormaechei subsp. xiangfangensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T156154 NZ_CP068829:c830799-830422 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT156154 WP_003863437.1 NZ_CP053103:c3822570-3822304 [Enterobacter hormaechei subsp. xiangfangensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT156154 NZ_CP068829:c831257-830889 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FG63

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References