Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3065610..3067393 Replicon chromosome
Accession NZ_CP053103
Organism Enterobacter hormaechei subsp. xiangfangensis strain Ec61

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HLA96_RS14490 Protein ID WP_045331150.1
Coordinates 3065610..3066959 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag HLA96_RS14495 Protein ID WP_003859317.1
Coordinates 3066956..3067393 (+) Length 146 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLA96_RS14465 3061433..3062368 - 936 WP_160858391.1 tRNA dihydrouridine(16) synthase DusC -
HLA96_RS14470 3062537..3062932 + 396 WP_003859308.1 CidA/LrgA family protein -
HLA96_RS14475 3062929..3063624 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
HLA96_RS14480 3063753..3064637 + 885 WP_003859312.1 cytidine deaminase -
HLA96_RS14485 3064765..3065475 + 711 WP_003859314.1 outer membrane permeability protein SanA -
HLA96_RS14490 3065610..3066959 + 1350 WP_045331150.1 type II toxin-antitoxin system HipA family toxin Toxin
HLA96_RS14495 3066956..3067393 + 438 WP_003859317.1 helix-turn-helix domain-containing protein Antitoxin
HLA96_RS14500 3067432..3068442 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
HLA96_RS14505 3068458..3069978 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
HLA96_RS14510 3070058..3071056 - 999 WP_045337654.1 galactose/glucose ABC transporter substrate-binding protein MglB -
HLA96_RS14515 3071352..3072374 - 1023 WP_045337656.1 HTH-type transcriptional regulator GalS -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(166-406)

Antitoxin

(75-128)


Sequences


Toxin        


Download         Length: 450 a.a.        Molecular weight: 51140.83 Da        Isoelectric Point: 4.6112

>T156152 WP_045331150.1 NZ_CP053103:3065610-3066959 [Enterobacter hormaechei subsp. xiangfangensis]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T156152 NZ_CP068829:c629602-629138 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT156152 WP_003859317.1 NZ_CP053103:3066956-3067393 [Enterobacter hormaechei subsp. xiangfangensis]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT156152 NZ_CP068829:c629937-629602 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References