Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2339759..2340498 Replicon chromosome
Accession NZ_CP053103
Organism Enterobacter hormaechei subsp. xiangfangensis strain Ec61

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HLA96_RS11135 Protein ID WP_047055520.1
Coordinates 2339759..2340244 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag HLA96_RS11140 Protein ID WP_045336276.1
Coordinates 2340232..2340498 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLA96_RS11105 2335250..2335822 + 573 WP_045346197.1 NAD(P)H-dependent oxidoreductase -
HLA96_RS11110 2335825..2336844 + 1020 WP_045346198.1 aldo/keto reductase -
HLA96_RS11115 2336883..2337260 + 378 WP_023292403.1 DUF1330 domain-containing protein -
HLA96_RS11120 2337297..2337902 + 606 WP_071957458.1 NAD(P)H-dependent oxidoreductase -
HLA96_RS11125 2337943..2338638 + 696 WP_045346199.1 antibiotic biosynthesis monooxygenase -
HLA96_RS11130 2338654..2339457 + 804 WP_045346200.1 carboxymuconolactone decarboxylase family protein -
HLA96_RS11135 2339759..2340244 - 486 WP_047055520.1 GNAT family N-acetyltransferase Toxin
HLA96_RS11140 2340232..2340498 - 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
HLA96_RS11145 2340562..2341491 - 930 WP_197620737.1 LysR family transcriptional regulator -
HLA96_RS11150 2341621..2343009 + 1389 WP_023324660.1 MFS transporter -
HLA96_RS11155 2343031..2344026 - 996 WP_023314163.1 DUF2891 domain-containing protein -
HLA96_RS11160 2344036..2345022 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2326259..2340498 14239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T156143 WP_047055520.1 NZ_CP053103:c2340244-2339759 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLGEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T156143 NZ_CP068828:3760839-3761057 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT156143 WP_045336276.1 NZ_CP053103:c2340498-2340232 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT156143 NZ_CP068828:3760439-3760813 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References