Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1143588..1144208 Replicon chromosome
Accession NZ_CP053103
Organism Enterobacter hormaechei subsp. xiangfangensis strain Ec61

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HLA96_RS05380 Protein ID WP_015571250.1
Coordinates 1143588..1143806 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HLA96_RS05385 Protein ID WP_006809850.1
Coordinates 1143834..1144208 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLA96_RS05350 1139600..1139860 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HLA96_RS05355 1139863..1140003 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HLA96_RS05360 1140000..1140710 - 711 WP_022650493.1 GNAT family N-acetyltransferase -
HLA96_RS05365 1140812..1142272 + 1461 WP_032608667.1 PLP-dependent aminotransferase family protein -
HLA96_RS05370 1142244..1142711 - 468 WP_022650495.1 hypothetical protein -
HLA96_RS05375 1142828..1143379 - 552 WP_022650496.1 maltose O-acetyltransferase -
HLA96_RS05380 1143588..1143806 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HLA96_RS05385 1143834..1144208 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HLA96_RS05390 1144719..1147865 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
HLA96_RS05395 1147888..1149081 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T156142 WP_015571250.1 NZ_CP053103:c1143806-1143588 [Enterobacter hormaechei subsp. xiangfangensis]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T156142 NZ_CP068828:3299390-3299776 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT156142 WP_006809850.1 NZ_CP053103:c1144208-1143834 [Enterobacter hormaechei subsp. xiangfangensis]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT156142 NZ_CP068828:3299766-3300095 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References