Detailed information of TA system TA156140

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 104528..105247
• Replicon: chromosome
• Accession: NZ_CP053103
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain Ec61

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HLA96_RS00530
• Protein ID: WP_040117033.1
• Coordinates: 104528..104848 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HLA96_RS00535
• Protein ID: WP_032620726.1
• Coordinates: 104882..105247 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLA96_RS00485	99640..100083	+	444	WP_045332974.1	GNAT family N-acetyltransferase	-
HLA96_RS00490	100116..100637	-	522	WP_032608180.1	hypothetical protein	-
HLA96_RS00495	100700..101065	-	366	WP_072031505.1	DUF2778 domain-containing protein	-
HLA96_RS00500	101075..101560	-	486	WP_045895876.1	type VI secretion system tube protein Hcp	-
HLA96_RS00505	101861..102163	-	303	Protein_100	hydroxyacid dehydrogenase	-
HLA96_RS00510	102222..102563	-	342	WP_160858717.1	SymE family type I addiction module toxin	-
HLA96_RS00515	102689..102880	+	192	WP_032610148.1	toxin-antitoxin system HicB family antitoxin	-
HLA96_RS00520	102930..103985	-	1056	WP_197620558.1	hypothetical protein	-
HLA96_RS00525	103960..104268	-	309	WP_197620560.1	hypothetical protein	-
HLA96_RS00530	104528..104848	-	321	WP_040117033.1	TA system toxin CbtA family protein	Toxin
HLA96_RS00535	104882..105247	-	366	WP_032620726.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HLA96_RS00540	105279..105500	-	222	WP_032620724.1	DUF987 domain-containing protein	-
HLA96_RS00545	105509..105979	-	471	WP_197620562.1	DNA repair protein RadC	-
HLA96_RS00550	106049..106870	-	822	WP_032620720.1	DUF945 domain-containing protein	-
HLA96_RS00555	107313..107504	-	192	WP_023305181.1	hypothetical protein	-
HLA96_RS00560	107563..108402	-	840	WP_049125417.1	hypothetical protein	-
HLA96_RS00565	108515..108949	-	435	WP_044488933.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12206.77 Da
• Isoelectric Point: 5.9558

>T156140 WP_040117033.1 NZ_CP053103:c104848-104528 [Enterobacter hormaechei subsp. xiangfangensis]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQYNLGLKRS

Nucleotide

• Length: 321 bp

>T156140 NZ_CP068828:2873582-2873689 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13574.29 Da
• Isoelectric Point: 6.4673

>AT156140 WP_032620726.1 NZ_CP053103:c105247-104882 [Enterobacter hormaechei subsp. xiangfangensis]
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Nucleotide

• Length: 366 bp

>AT156140 NZ_CP068828:c2873532-2873469 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT