Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2166065..2166579 Replicon chromosome
Accession NZ_CP053101
Organism Staphylococcus aureus strain EDCC5398

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HLB22_RS10710 Protein ID WP_000581792.1
Coordinates 2166065..2166274 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag HLB22_RS10715 Protein ID WP_000138928.1
Coordinates 2166286..2166579 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB22_RS10690 2161573..2162931 - 1359 WP_000611469.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
HLB22_RS10695 2162946..2164016 - 1071 WP_000159632.1 D-alanine--D-alanine ligase -
HLB22_RS10700 2164334..2165536 + 1203 WP_001109944.1 rod shape-determining protein RodA -
HLB22_RS10705 2165800..2165937 - 138 WP_000828354.1 hypothetical protein -
HLB22_RS10710 2166065..2166274 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HLB22_RS10715 2166286..2166579 - 294 WP_000138928.1 copper-sensing transcriptional repressor CsoR Antitoxin
HLB22_RS10720 2166745..2168229 + 1485 WP_000571551.1 cardiolipin synthase -
HLB22_RS10725 2168257..2168904 + 648 WP_001187617.1 HD domain-containing protein -
HLB22_RS10730 2169382..2170254 - 873 WP_000725802.1 membrane protein insertase YidC -
HLB22_RS10735 2170340..2170981 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T156103 WP_000581792.1 NZ_CP053101:c2166274-2166065 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T156103 NZ_CP068827:c1736550-1736215 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11184.82 Da        Isoelectric Point: 6.2243

>AT156103 WP_000138928.1 NZ_CP053101:c2166579-2166286 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT156103 NZ_CP068827:c1736798-1736550 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure

References