Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2146309..2146838 Replicon chromosome
Accession NZ_CP053101
Organism Staphylococcus aureus strain EDCC5398

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HLB22_RS10620 Protein ID WP_000621175.1
Coordinates 2146309..2146671 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HLB22_RS10625 Protein ID WP_000948330.1
Coordinates 2146668..2146838 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB22_RS10600 2143287..2144057 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
HLB22_RS10605 2144032..2144511 - 480 WP_001190825.1 anti-sigma B factor RsbW -
HLB22_RS10610 2144513..2144839 - 327 WP_001052491.1 anti-sigma factor antagonist -
HLB22_RS10615 2144959..2145960 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
HLB22_RS10620 2146309..2146671 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HLB22_RS10625 2146668..2146838 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HLB22_RS10630 2146923..2148071 - 1149 WP_001281141.1 alanine racemase -
HLB22_RS10635 2148137..2148496 - 360 WP_000581193.1 holo-ACP synthase -
HLB22_RS10640 2148500..2148991 - 492 WP_001205918.1 PH domain-containing protein -
HLB22_RS10645 2148978..2150561 - 1584 WP_001294624.1 PH domain-containing protein -
HLB22_RS10650 2150554..2151033 - 480 WP_001287080.1 hypothetical protein -
HLB22_RS10655 2151242..2151802 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T156102 WP_000621175.1 NZ_CP053101:c2146671-2146309 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T156102 NZ_CP068827:c1662498-1662187 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT156102 WP_000948330.1 NZ_CP053101:c2146838-2146668 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT156102 NZ_CP068827:c1662190-1661771 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References