Detailed information of TA system TA156099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1934404..1935180
• Replicon: chromosome
• Accession: NZ_CP053101
• Organism: Staphylococcus aureus strain EDCC5398

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: HLB22_RS09315
• Protein ID: WP_000031112.1
• Coordinates: 1934404..1934556 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: HLB22_RS09320
• Protein ID: WP_001251224.1
• Coordinates: 1934581..1935180 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HLB22_RS09300	1930310..1931131	+	822	WP_000669382.1	RluA family pseudouridine synthase	-
HLB22_RS09305	1931593..1932978	-	1386	WP_000116232.1	class II fumarate hydratase	-
HLB22_RS09310	1933174..1933569	-	396	WP_000901023.1	hypothetical protein	-
HLB22_RS09315	1934404..1934556	-	153	WP_000031112.1	hypothetical protein	Toxin
HLB22_RS09320	1934581..1935180	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
HLB22_RS09325	1935339..1935809	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
HLB22_RS09330	1935814..1936941	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
HLB22_RS09335	1937091..1937813	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
HLB22_RS09340	1937806..1939263	-	1458	WP_000649910.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5966.31 Da
• Isoelectric Point: 3.8962

>T156099 WP_000031112.1 NZ_CP053101:c1934556-1934404 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELSKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T156099 NZ_CP068827:896066-896440 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCTGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT156099 WP_001251224.1 NZ_CP053101:c1935180-1934581 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT156099 NZ_CP068827:895609-895977 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4