Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 832916..833393 Replicon chromosome
Accession NZ_CP053101
Organism Staphylococcus aureus strain EDCC5398

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HLB22_RS03860 Protein ID WP_000052076.1
Coordinates 832916..833104 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HLB22_RS03865 Protein ID WP_001059690.1
Coordinates 833133..833393 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB22_RS03830 828906..829427 + 522 WP_000824488.1 hypothetical protein -
HLB22_RS03835 829768..830454 + 687 WP_001670297.1 thermonuclease family protein -
HLB22_RS03840 830811..831011 + 201 WP_001059082.1 cold-shock protein -
HLB22_RS03845 831507..831725 - 219 WP_000005876.1 hypothetical protein -
HLB22_RS03850 831787..832071 - 285 WP_001004395.1 hypothetical protein -
HLB22_RS03855 832159..832728 - 570 WP_001106646.1 hypothetical protein -
HLB22_RS03860 832916..833104 - 189 WP_000052076.1 hypothetical protein Toxin
HLB22_RS03865 833133..833393 - 261 WP_001059690.1 hypothetical protein Antitoxin
HLB22_RS03870 833733..833936 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HLB22_RS03875 833933..834169 - 237 WP_000368687.1 hypothetical protein -
HLB22_RS03880 834394..834975 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
HLB22_RS03885 835048..835665 - 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
HLB22_RS03890 835818..836312 - 495 WP_000590539.1 GNAT family N-acetyltransferase -
HLB22_RS03895 836711..837133 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
HLB22_RS03900 837281..837997 + 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T156090 WP_000052076.1 NZ_CP053101:c833104-832916 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T156090 NZ_CP068826:c4554009-4553719 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT156090 WP_001059690.1 NZ_CP053101:c833393-833133 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT156090 NZ_CP068826:c4554241-4553999 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References