156088

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2314..2842 Replicon plasmid unnamed2
Accession NZ_CP053100
Organism Acinetobacter baumannii ATCC 17978

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag HKO16_RS19215 Protein ID WP_000221358.1
Coordinates 2549..2842 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag HKO16_RS19210 Protein ID WP_000246756.1
Coordinates 2314..2559 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKO16_RS19190 1..951 + 951 WP_001205343.1 replication initiation protein RepM -
HKO16_RS19195 944..1519 + 576 WP_001096616.1 helix-turn-helix domain-containing protein -
HKO16_RS19200 1539..1682 + 144 WP_001125244.1 hypothetical protein -
HKO16_RS19205 1867..2070 - 204 WP_000482656.1 hypothetical protein -
HKO16_RS19210 2314..2559 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HKO16_RS19215 2549..2842 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKO16_RS19220 3060..4262 + 1203 WP_061855756.1 alpha/beta fold hydrolase -
HKO16_RS19225 4360..5133 + 774 WP_061855758.1 glucose 1-dehydrogenase -
HKO16_RS19230 5480..5767 + 288 WP_000438826.1 BrnT family toxin -
HKO16_RS19235 5754..6068 + 315 WP_061855757.1 BrnA antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11302 11302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T156088 WP_000221358.1 NZ_CP053100:2549-2842 [Acinetobacter baumannii ATCC 17978]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T156088 NZ_CP068826:c4384405-4384196 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT156088 WP_000246756.1 NZ_CP053100:2314-2559 [Acinetobacter baumannii ATCC 17978]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT156088 NZ_CP068826:c4384199-4383897 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References