Detailed information of TA system TA156084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1933637..1935273
• Replicon: chromosome
• Accession: NZ_CP053098
• Organism: Acinetobacter baumannii ATCC 17978

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: HKO16_RS09195
• Protein ID: WP_000737056.1
• Coordinates: 1933942..1935273 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HKO16_RS09190
• Protein ID: WP_001101308.1
• Coordinates: 1933637..1933945 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKO16_RS09165	1929201..1929719	-	519	WP_000651611.1	GNAT family N-acetyltransferase	-
HKO16_RS09170	1929867..1930382	-	516	WP_000914805.1	hypothetical protein	-
HKO16_RS09175	1930424..1931506	-	1083	WP_001095788.1	ImmA/IrrE family metallo-endopeptidase	-
HKO16_RS09180	1931524..1932144	-	621	WP_000658761.1	hypothetical protein	-
HKO16_RS09185	1932360..1932911	-	552	WP_049594830.1	TetR/AcrR family transcriptional regulator	-
HKO16_RS09190	1933637..1933945	-	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
HKO16_RS09195	1933942..1935273	-	1332	WP_000737056.1	type II toxin-antitoxin system HipA family toxin	Toxin
HKO16_RS09200	1935569..1936009	+	441	WP_000193135.1	HD domain-containing protein	-
HKO16_RS09205	1936044..1936688	-	645	WP_000817301.1	hypothetical protein	-
HKO16_RS09210	1936700..1937671	-	972	WP_109104914.1	acid phosphatase	-
HKO16_RS09215	1937798..1938958	-	1161	WP_001044492.1	hypothetical protein	-
HKO16_RS09220	1938951..1940189	-	1239	WP_011859301.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T156084 WP_000737056.1 NZ_CP053098:c1935273-1933942 [Acinetobacter baumannii ATCC 17978]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T156084 NZ_CP068826:3426031-3426417 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT156084 WP_001101308.1 NZ_CP053098:c1933945-1933637 [Acinetobacter baumannii ATCC 17978]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT156084 NZ_CP068826:3426407-3426736 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1