156066

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2917624..2918338 Replicon chromosome
Accession NZ_CP053092
Organism Mycobacterium tuberculosis strain 4860

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag HGO90_RS13625 Protein ID WP_003413460.1
Coordinates 2917898..2918338 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag HGO90_RS13620 Protein ID WP_003413456.1
Coordinates 2917624..2917911 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO90_RS13585 2913046..2913291 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HGO90_RS13590 2913288..2913692 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
HGO90_RS13595 2913909..2914529 + 621 WP_003413441.1 DUF4178 domain-containing protein -
HGO90_RS13600 2914540..2915034 + 495 WP_003413444.1 DUF2617 family protein -
HGO90_RS13605 2915031..2915462 + 432 WP_003899390.1 DUF4247 domain-containing protein -
HGO90_RS13610 2915487..2915945 + 459 WP_003413451.1 DUF350 domain-containing protein -
HGO90_RS13615 2915942..2917513 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
HGO90_RS13620 2917624..2917911 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
HGO90_RS13625 2917898..2918338 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
HGO90_RS13630 2918359..2919114 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
HGO90_RS13635 2919247..2919843 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
HGO90_RS13640 2919851..2920696 - 846 WP_003413466.1 acyl-CoA thioesterase II -
HGO90_RS13645 2920725..2921624 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
HGO90_RS13650 2921752..2922426 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T156066 WP_003413460.1 NZ_CP053092:2917898-2918338 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T156066 NZ_CP068825:4220664-4221128 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGGCAGAAGAAACCCATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT156066 WP_003413456.1 NZ_CP053092:2917624-2917911 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT156066 NZ_CP068825:4220329-4220664 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACACC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References