Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2855709..2856418 Replicon chromosome
Accession NZ_CP053092
Organism Mycobacterium tuberculosis strain 4860

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag HGO90_RS13340 Protein ID WP_003413164.1
Coordinates 2855709..2856122 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag HGO90_RS13345 Protein ID WP_003413167.1
Coordinates 2856161..2856418 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO90_RS13310 2850762..2851967 - 1206 WP_003413027.1 chorismate synthase -
HGO90_RS13315 2852075..2852389 + 315 WP_009937839.1 hypothetical protein -
HGO90_RS13320 2852685..2853896 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
HGO90_RS13325 2854023..2854682 + 660 WP_014585545.1 LppA family lipoprotein -
HGO90_RS13330 2854679..2855341 + 663 WP_003900848.1 hypothetical protein -
HGO90_RS13335 2855338..2855616 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
HGO90_RS13340 2855709..2856122 + 414 WP_003413164.1 PIN domain nuclease Toxin
HGO90_RS13345 2856161..2856418 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
HGO90_RS13350 2856415..2856792 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
HGO90_RS13355 2856808..2857182 - 375 WP_003413177.1 hypothetical protein -
HGO90_RS13360 2857282..2857677 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
HGO90_RS13365 2857674..2857919 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
HGO90_RS13370 2858330..2858749 - 420 WP_003413190.1 A24 family peptidase -
HGO90_RS13375 2858761..2859570 - 810 WP_003413193.1 shikimate dehydrogenase -
HGO90_RS13380 2859567..2860820 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
HGO90_RS13385 2860813..2861325 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T156063 WP_003413164.1 NZ_CP053092:2855709-2856122 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T156063 NZ_CP068825:c3956850-3956443 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGAAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT156063 WP_003413167.1 NZ_CP053092:2856161-2856418 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT156063 NZ_CP068825:c3957097-3956831 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References