Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2389710..2390239 Replicon chromosome
Accession NZ_CP053092
Organism Mycobacterium tuberculosis strain 4860

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag HGO90_RS11145 Protein ID WP_003411124.1
Coordinates 2389710..2390027 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag HGO90_RS11150 Protein ID WP_003411127.1
Coordinates 2390024..2390239 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO90_RS11115 2384905..2385981 + 1077 WP_003411110.1 hypothetical protein -
HGO90_RS11120 2385978..2386259 + 282 WP_003411112.1 hypothetical protein -
HGO90_RS11125 2386295..2387368 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
HGO90_RS11130 2387373..2387903 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
HGO90_RS11135 2387951..2389297 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
HGO90_RS11145 2389710..2390027 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGO90_RS11150 2390024..2390239 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
HGO90_RS11155 2390494..2391552 + 1059 WP_003411129.1 hypothetical protein -
HGO90_RS11160 2391682..2392038 - 357 WP_003411130.1 hypothetical protein -
HGO90_RS11165 2392133..2392915 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
HGO90_RS11170 2393183..2393473 - 291 WP_003900476.1 YggT family protein -
HGO90_RS11175 2393635..2394291 - 657 WP_003411133.1 cell division protein SepF -
HGO90_RS11180 2394357..2395133 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T156060 WP_003411124.1 NZ_CP053092:c2390027-2389710 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T156060 NZ_CP068825:c2311297-2311019 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT156060 WP_003411127.1 NZ_CP053092:c2390239-2390024 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT156060 NZ_CP068825:c2311019-2310735 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References