156053

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2207946..2208634 Replicon chromosome
Accession NZ_CP053092
Organism Mycobacterium tuberculosis strain 4860

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag HGO90_RS10290 Protein ID WP_003409958.1
Coordinates 2207946..2208365 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag HGO90_RS10295 Protein ID WP_003409968.1
Coordinates 2208374..2208634 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO90_RS10270 2203696..2204289 + 594 Protein_2020 class I SAM-dependent methyltransferase -
HGO90_RS10275 2204252..2205697 - 1446 WP_003899115.1 APC family permease -
HGO90_RS10280 2205876..2206562 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
HGO90_RS10285 2206753..2207721 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
HGO90_RS10290 2207946..2208365 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
HGO90_RS10295 2208374..2208634 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HGO90_RS10300 2208777..2210453 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
HGO90_RS10305 2210441..2211094 - 654 WP_003409976.1 cutinase Cfp21 -
HGO90_RS10310 2211209..2211439 + 231 WP_003409980.1 DUF167 domain-containing protein -
HGO90_RS10315 2211524..2212435 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
HGO90_RS10320 2212544..2213143 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T156053 WP_003409958.1 NZ_CP053092:c2208365-2207946 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T156053 NZ_CP068825:941454-941795 [Escherichia coli]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTACTTGC
TGCAATGCTGATTCTTGCTGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGATACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCGGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT156053 WP_003409968.1 NZ_CP053092:c2208634-2208374 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT156053 NZ_CP068825:941805-942104 [Escherichia coli]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGTGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACTCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCGAATGGTAAGAGAATTGCATTTCAGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References