Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2184854..2185398 Replicon chromosome
Accession NZ_CP053092
Organism Mycobacterium tuberculosis strain 4860

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag HGO90_RS10160 Protein ID WP_003409896.1
Coordinates 2184854..2185150 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag HGO90_RS10165 Protein ID WP_003409899.1
Coordinates 2185147..2185398 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO90_RS10105 2179887..2180237 - 351 WP_003899096.1 hypothetical protein -
HGO90_RS10110 2180248..2181150 - 903 WP_003899097.1 hypothetical protein -
HGO90_RS10115 2181171..2181362 - 192 WP_003409876.1 hypothetical protein -
HGO90_RS10120 2181363..2181659 - 297 WP_003409877.1 hypothetical protein -
HGO90_RS10125 2181899..2182114 + 216 WP_003409878.1 antitoxin -
HGO90_RS10130 2182111..2182422 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
HGO90_RS10135 2182396..2182917 - 522 WP_003904745.1 hypothetical protein -
HGO90_RS10140 2182892..2183269 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
HGO90_RS10145 2183311..2183760 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
HGO90_RS10150 2183757..2184302 + 546 WP_003409891.1 SecB-like chaperone -
HGO90_RS10155 2184191..2184805 - 615 WP_003901296.1 hypothetical protein -
HGO90_RS10160 2184854..2185150 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGO90_RS10165 2185147..2185398 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HGO90_RS10170 2185385..2185879 + 495 WP_003899099.1 hypothetical protein -
HGO90_RS10175 2186039..2186446 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
HGO90_RS10180 2186450..2186722 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HGO90_RS10185 2186755..2187975 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
HGO90_RS10190 2188874..2189671 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T156052 WP_003409896.1 NZ_CP053092:c2185150-2184854 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T156052 NZ_CP068825:c638584-638432 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT156052 WP_003409899.1 NZ_CP053092:c2185398-2185147 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT156052 NZ_CP068825:638633-638690 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References