Detailed information of TA system TA156042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1385834..1386522
• Replicon: chromosome
• Accession: NZ_CP053092
• Organism: Mycobacterium tuberculosis strain 4860

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: HGO90_RS06545
• Protein ID: WP_003406304.1
• Coordinates: 1386091..1386522 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: HGO90_RS06540
• Protein ID: WP_003406302.1
• Coordinates: 1385834..1386094 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO90_RS06520	1381411..1382235	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
HGO90_RS06525	1382240..1383421	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
HGO90_RS06530	1383498..1384598	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
HGO90_RS06535	1384769..1385758	+	990	WP_003406301.1	malate dehydrogenase	-
HGO90_RS06540	1385834..1386094	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
HGO90_RS06545	1386091..1386522	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
HGO90_RS06550	1386545..1388233	-	1689	WP_003910308.1	PE family protein	-
HGO90_RS06555	1388413..1389273	+	861	WP_003900301.1	hypothetical protein	-
HGO90_RS06560	1389354..1390184	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
HGO90_RS06565	1390241..1390534	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
HGO90_RS06570	1390531..1390800	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T156042 WP_003406304.1 NZ_CP053092:1386091-1386522 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T156042 NZ_CP068824:c4384450-4384241 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT156042 WP_003406302.1 NZ_CP053092:1385834-1386094 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT156042 NZ_CP068824:c4384244-4383942 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6