Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 753346..753979 Replicon chromosome
Accession NZ_CP053092
Organism Mycobacterium tuberculosis strain 4860

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag HGO90_RS03450 Protein ID WP_003403365.1
Coordinates 753346..753729 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag HGO90_RS03455 Protein ID WP_003403368.1
Coordinates 753824..753979 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO90_RS03425 748638..749174 + 537 WP_003403341.1 50S ribosomal protein L10 -
HGO90_RS03430 749211..749603 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
HGO90_RS03435 749596..750291 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
HGO90_RS03440 750362..751867 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
HGO90_RS03445 751948..752958 + 1011 WP_009937374.1 ABC transporter ATP-binding protein -
HGO90_RS03450 753346..753729 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
HGO90_RS03455 753824..753979 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HGO90_RS03460 754055..754771 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
HGO90_RS03465 755047..755355 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
HGO90_RS03470 755342..755587 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
HGO90_RS03475 755697..756134 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
HGO90_RS03480 756131..756385 - 255 WP_003911263.1 antitoxin VapB7 -
HGO90_RS03485 756499..758862 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T156032 WP_003403365.1 NZ_CP053092:c753729-753346 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T156032 NZ_CP068824:2235692-2235795 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT156032 WP_003403368.1 NZ_CP053092:c753979-753824 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT156032 NZ_CP068824:c2235833-2235562 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References