Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 446721..447732 Replicon chromosome
Accession NZ_CP053092
Organism Mycobacterium tuberculosis strain 4860

Toxin (Protein)


Gene name pezT Uniprot ID A0A655I6S7
Locus tag HGO90_RS01930 Protein ID WP_003906352.1
Coordinates 446721..447314 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag HGO90_RS01935 Protein ID WP_003401860.1
Coordinates 447343..447732 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO90_RS01910 442370..443752 + 1383 WP_003898415.1 magnesium transporter -
HGO90_RS01915 443764..444798 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
HGO90_RS01920 444894..445577 + 684 WP_003401857.1 VTT domain-containing protein -
HGO90_RS01925 445566..446696 - 1131 WP_003401858.1 hypothetical protein -
HGO90_RS01930 446721..447314 - 594 WP_003906352.1 zeta toxin family protein Toxin
HGO90_RS01935 447343..447732 - 390 WP_003401860.1 hypothetical protein Antitoxin
HGO90_RS01940 447813..449024 - 1212 WP_003906353.1 VWA domain-containing protein -
HGO90_RS01945 449030..449632 - 603 WP_003898417.1 SRPBCC family protein -
HGO90_RS01950 449646..450542 - 897 WP_003898418.1 MoxR family ATPase -
HGO90_RS01955 450539..451132 - 594 WP_003401864.1 NTP transferase domain-containing protein -
HGO90_RS01960 451129..451884 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21358.60 Da        Isoelectric Point: 10.6337

>T156023 WP_003906352.1 NZ_CP053092:c447314-446721 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDKSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T156023 NZ_CP068824:216762-216869 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT156023 WP_003401860.1 NZ_CP053092:c447732-447343 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT156023 NZ_CP068824:c216704-216650 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A655I6S7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References