Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4951882..4952537 Replicon chromosome
Accession NZ_CP053085
Organism Gemmatimonas sp. TET16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HKW67_RS21320 Protein ID WP_171227319.1
Coordinates 4952151..4952537 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HKW67_RS21315 Protein ID WP_171227318.1
Coordinates 4951882..4952154 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKW67_RS21305 4947714..4949666 - 1953 WP_171227316.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
HKW67_RS21310 4949844..4950797 - 954 WP_171227317.1 diguanylate cyclase -
HKW67_RS21315 4951882..4952154 + 273 WP_171227318.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HKW67_RS21320 4952151..4952537 + 387 WP_171227319.1 type II toxin-antitoxin system VapC family toxin Toxin
HKW67_RS21325 4952682..4953428 + 747 WP_171227320.1 tetratricopeptide repeat protein -
HKW67_RS21330 4953450..4954205 - 756 WP_171227321.1 amidohydrolase family protein -
HKW67_RS21335 4954571..4954858 + 288 WP_171227322.1 hypothetical protein -
HKW67_RS21340 4955067..4955396 - 330 WP_171227323.1 hypothetical protein -
HKW67_RS21345 4955540..4955935 - 396 WP_171227324.1 BrnA antitoxin family protein -
HKW67_RS22360 4955928..4956164 - 237 WP_206044527.1 BrnT family toxin -
HKW67_RS21355 4956446..4956748 + 303 WP_171227326.1 hypothetical protein -
HKW67_RS21360 4957091..4957390 - 300 WP_206044528.1 HEAT repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-122)

Antitoxin

Antitoxin VapB-like

(2-87)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13531.63 Da        Isoelectric Point: 4.5851

>T156014 WP_171227319.1 NZ_CP053085:4952151-4952537 [Gemmatimonas sp. TET16]
VILDSSALVAIVLQEQAAERLLQRMRDASFLAIGAATLLETGIVLSARLHDDARGLLARVLQESGITVVDVTEAHFGVAM
DAWLRYGKGRHPAALNFGDCLSYAIAVVAGAPLLCVGDDFPQTDCVLA

Download         Length: 387 bp

>T156014 NZ_CP068823:c3808290-3807892 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10198.59 Da        Isoelectric Point: 9.9824

>AT156014 WP_171227318.1 NZ_CP053085:4951882-4952154 [Gemmatimonas sp. TET16]
VAVNIKNKRVERLLDEVAALTGETKTEAIRRALEERRDRLARSSAQLHPADRLRRLLEREIWPSIPADVRGTRLSKAEEE
QILGYGPDGA

Download         Length: 273 bp

>AT156014 NZ_CP068823:c3808586-3808293 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References