Detailed information of TA system TA156013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4597583..4598160
• Replicon: chromosome
• Accession: NZ_CP053085
• Organism: Gemmatimonas sp. TET16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HKW67_RS19680
• Protein ID: WP_206044507.1
• Coordinates: 4597861..4598160 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HKW67_RS19675
• Protein ID: WP_171227011.1
• Coordinates: 4597583..4597864 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKW67_RS19665	4593089..4595644	+	2556	WP_171227009.1	hypothetical protein	-
HKW67_RS19670	4596120..4597157	+	1038	WP_171227010.1	hypothetical protein	-
HKW67_RS19675	4597583..4597864	+	282	WP_171227011.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HKW67_RS19680	4597861..4598160	+	300	WP_206044507.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HKW67_RS19685	4598472..4599560	-	1089	WP_206044508.1	redoxin domain-containing protein	-
HKW67_RS19690	4599611..4599925	-	315	WP_206044509.1	cupin domain-containing protein	-
HKW67_RS19695	4600112..4601575	-	1464	WP_206044510.1	epoxide hydrolase N-terminal domain-containing protein	-
HKW67_RS19700	4601714..4602349	-	636	WP_171227014.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11495.18 Da
• Isoelectric Point: 5.7424

>T156013 WP_206044507.1 NZ_CP053085:4597861-4598160 [Gemmatimonas sp. TET16]
MKVVWSPLAEQRALEAVEYIAQDRPRTAAVWLEGLLERVSQLDRFEEQGRVVSEIGIPAYREILHAPYRIIYRVDASRVV
ILTLRHVRRAWDPAEVDDA

Nucleotide

• Length: 300 bp

>T156013 NZ_CP068823:3624770-3625312 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10250.74 Da
• Isoelectric Point: 10.0778

>AT156013 WP_171227011.1 NZ_CP053085:4597583-4597864 [Gemmatimonas sp. TET16]
MSKLRPSRDIQPVTEFRANAAQFIEQVQATGEPVILTQHGRSAAVLLDVESYEGMLDELALLRDVRQAEQQVAAGKTVTH
AAVAKRLRARLGR

Nucleotide

• Length: 282 bp

>AT156013 NZ_CP068823:3624475-3624786 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA