Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4120646..4121331 Replicon chromosome
Accession NZ_CP053085
Organism Gemmatimonas sp. TET16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HKW67_RS17615 Protein ID WP_171226637.1
Coordinates 4120903..4121331 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HKW67_RS17610 Protein ID WP_171226636.1
Coordinates 4120646..4120903 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKW67_RS17590 4116018..4116746 + 729 WP_171226632.1 ABC transporter ATP-binding protein -
HKW67_RS17595 4116739..4119117 + 2379 WP_171226633.1 ABC transporter permease -
HKW67_RS17600 4119121..4119729 - 609 WP_171226634.1 TetR/AcrR family transcriptional regulator -
HKW67_RS17605 4119804..4120613 + 810 WP_171226635.1 glucose 1-dehydrogenase -
HKW67_RS17610 4120646..4120903 + 258 WP_171226636.1 hypothetical protein Antitoxin
HKW67_RS17615 4120903..4121331 + 429 WP_171226637.1 PIN domain-containing protein Toxin
HKW67_RS17620 4121421..4121852 - 432 WP_171226638.1 phosphate ABC transporter substrate-binding protein -
HKW67_RS17625 4121863..4122981 - 1119 WP_171226639.1 hypothetical protein -
HKW67_RS17630 4123271..4123789 + 519 WP_171226640.1 ferritin-like domain-containing protein -
HKW67_RS17635 4123933..4124418 - 486 WP_206044478.1 DUF4256 domain-containing protein -
HKW67_RS17640 4124690..4126123 + 1434 WP_171226642.1 DUF3300 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-135)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15289.52 Da        Isoelectric Point: 6.4854

>T156012 WP_171226637.1 NZ_CP053085:4120903-4121331 [Gemmatimonas sp. TET16]
MRALLDVNVLIALFDADHISHHAAVAWFAANAVNGWASCPITQNGCVRIMSHPGYPGAHAVVDIVGKLRRASLESVHEFW
ADDVSVLDDQLFDTTRIHGPRQLTDVYLLALAVRHGGVLVTFDRSIAVDAVRGATAASLVVL

Download         Length: 429 bp

>T156012 NZ_CP068823:3590785-3591003 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9309.57 Da        Isoelectric Point: 7.2012

>AT156012 WP_171226636.1 NZ_CP053085:4120646-4120903 [Gemmatimonas sp. TET16]
MRTTLDIADDVLAAAKERAKREHKSMGQVVSELMRQALTAPRESSGLAPSAVHEPPAIYGVQPFASRGAVVTNDLIYRLR
QDDAY

Download         Length: 258 bp

>AT156012 NZ_CP068823:3590385-3590759 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References