Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2858919..2859358 Replicon chromosome
Accession NZ_CP053085
Organism Gemmatimonas sp. TET16

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKW67_RS12075 Protein ID WP_206044400.1
Coordinates 2859152..2859358 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKW67_RS12070 Protein ID WP_171225624.1
Coordinates 2858919..2859128 (+) Length 70 a.a.

Genomic Context

HKW67_RS12070HKW67_RS12075HKW67_RS12090HKW67_RS12055HKW67_RS12060HKW67_RS12065HKW67_RS12080HKW67_RS12085
Location: 2858919..2859128 (210 bp)
Type: Antitoxin
Protein ID: WP_171225624.1
Location: 2859152..2859358 (207 bp)
Type: Toxin
Protein ID: WP_206044400.1
Location: 2862455..2863729 (1275 bp)
Type: Others
Protein ID: WP_171225628.1
Location: 2855706..2856233 (528 bp)
Type: Others
Protein ID: WP_171225621.1
Location: 2856230..2858185 (1956 bp)
Type: Others
Protein ID: WP_171225622.1
Location: 2858182..2858604 (423 bp)
Type: Others
Protein ID: WP_171225623.1
Location: 2859563..2860744 (1182 bp)
Type: Others
Protein ID: WP_171225626.1
Location: 2860972..2862168 (1197 bp)
Type: Others
Protein ID: WP_171225627.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HKW67_RS120552855706..2856233-528WP_171225621.1hypothetical protein-
HKW67_RS120602856230..2858185-1956WP_171225622.1Ig-like domain-containing protein-
HKW67_RS120652858182..2858604-423WP_171225623.1hypothetical protein-
HKW67_RS120702858919..2859128+210WP_171225624.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
HKW67_RS120752859152..2859358+207WP_206044400.1type II toxin-antitoxin system HicA family toxinToxin
HKW67_RS120802859563..2860744-1182WP_171225626.1MFS transporter-
HKW67_RS120852860972..2862168-1197WP_171225627.1hypothetical protein-
HKW67_RS120902862455..2863729+1275WP_171225628.1VWA domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7456.56 Da        Isoelectric Point: 10.6934

>T156011 WP_206044400.1 NZ_CP053085:2859152-2859358 [Gemmatimonas sp. TET16]
MRPREVIAVLTALGFVEVRQQGSHKQFRHADGRGTTVPDHGGRDISPVLIRQIAKDVGLSADELLALR

Download         Length: 207 bp

>T156011 NZ_CP068823:c3562987-3562685 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7482.34 Da        Isoelectric Point: 3.7003

>AT156011 WP_171225624.1 NZ_CP053085:2858919-2859128 [Gemmatimonas sp. TET16]
MGTYTAVIERDQSTGLYVGYVPGWAGAHSQGESLDELRANLYEVMLMLLEDGEPALSTEFVGTQTLEVA

Download         Length: 210 bp

>AT156011 NZ_CP068823:c3562649-3562308 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References