Detailed information of TA system TA156011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2858919..2859358
• Replicon: chromosome
• Accession: NZ_CP053085
• Organism: Gemmatimonas sp. TET16

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HKW67_RS12075
• Protein ID: WP_206044400.1
• Coordinates: 2859152..2859358 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HKW67_RS12070
• Protein ID: WP_171225624.1
• Coordinates: 2858919..2859128 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKW67_RS12055	2855706..2856233	-	528	WP_171225621.1	hypothetical protein	-
HKW67_RS12060	2856230..2858185	-	1956	WP_171225622.1	Ig-like domain-containing protein	-
HKW67_RS12065	2858182..2858604	-	423	WP_171225623.1	hypothetical protein	-
HKW67_RS12070	2858919..2859128	+	210	WP_171225624.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HKW67_RS12075	2859152..2859358	+	207	WP_206044400.1	type II toxin-antitoxin system HicA family toxin	Toxin
HKW67_RS12080	2859563..2860744	-	1182	WP_171225626.1	MFS transporter	-
HKW67_RS12085	2860972..2862168	-	1197	WP_171225627.1	hypothetical protein	-
HKW67_RS12090	2862455..2863729	+	1275	WP_171225628.1	VWA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7456.56 Da
• Isoelectric Point: 10.6934

>T156011 WP_206044400.1 NZ_CP053085:2859152-2859358 [Gemmatimonas sp. TET16]
MRPREVIAVLTALGFVEVRQQGSHKQFRHADGRGTTVPDHGGRDISPVLIRQIAKDVGLSADELLALR

Nucleotide

• Length: 207 bp

>T156011 NZ_CP068823:c3562987-3562685 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7482.34 Da
• Isoelectric Point: 3.7003

>AT156011 WP_171225624.1 NZ_CP053085:2858919-2859128 [Gemmatimonas sp. TET16]
MGTYTAVIERDQSTGLYVGYVPGWAGAHSQGESLDELRANLYEVMLMLLEDGEPALSTEFVGTQTLEVA

Nucleotide

• Length: 210 bp

>AT156011 NZ_CP068823:c3562649-3562308 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG