Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(antitoxin)
Location 702687..703255 Replicon chromosome
Accession NZ_CP053085
Organism Gemmatimonas sp. TET16

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HKW67_RS02870 Protein ID WP_171223961.1
Coordinates 702687..702926 (+) Length 80 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HKW67_RS02875 Protein ID WP_171223962.1
Coordinates 702920..703255 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKW67_RS22250 697943..699877 + 1935 WP_206044583.1 HupE/UreJ family protein -
HKW67_RS02860 699888..702098 + 2211 WP_171223959.1 PQQ-binding-like beta-propeller repeat protein -
HKW67_RS02865 702206..702607 + 402 WP_206044584.1 hypothetical protein -
HKW67_RS02870 702687..702926 + 240 WP_171223961.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
HKW67_RS02875 702920..703255 + 336 WP_171223962.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
HKW67_RS02880 703271..704290 - 1020 WP_206044695.1 hypothetical protein -
HKW67_RS02885 704531..705097 + 567 WP_171223964.1 Uma2 family endonuclease -
HKW67_RS02890 705142..706002 + 861 WP_206044585.1 MBL fold metallo-hydrolase -
HKW67_RS02895 706323..707528 + 1206 WP_171223965.1 radical SAM protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(7-109)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 8613.79 Da        Isoelectric Point: 4.7558

>T156010 WP_171223961.1 NZ_CP053085:702687-702926 [Gemmatimonas sp. TET16]
MKGKLVRIGNSRGVRLAKPLIEEAGLTDDVEIRVQGGALIITSVESPRAGWAESVTKYGPSKLLDEPSATVFDESEWTW

Download         Length: 240 bp

>T156010 NZ_CP068823:3212597-3212983 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAGGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12111.13 Da        Isoelectric Point: 10.5442

>AT156010 WP_171223962.1 NZ_CP053085:702920-703255 [Gemmatimonas sp. TET16]
MVTAGSVHRGEVYTVELNPTRGREIRKTRPCVIVSPDELNAALGTFIVAPLTTGGHPYPFRVSCRFAGKDGHVVLDQIRT
VDRERIGKRLGVLTAPTQAKILVVLQAMFTA

Download         Length: 336 bp

>AT156010 NZ_CP068823:3212973-3213302 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References