Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(antitoxin)
Location 702687..703255 Replicon chromosome
Accession NZ_CP053085
Organism Gemmatimonas sp. TET16

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HKW67_RS02870 Protein ID WP_171223961.1
Coordinates 702687..702926 (+) Length 80 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HKW67_RS02875 Protein ID WP_171223962.1
Coordinates 702920..703255 (+) Length 112 a.a.

Genomic Context

HKW67_RS22250HKW67_RS02860HKW67_RS02865HKW67_RS02870HKW67_RS02875HKW67_RS02885HKW67_RS02890HKW67_RS02895HKW67_RS02880
Location: 697943..699877 (1935 bp)
Type: Others
Protein ID: WP_206044583.1
Location: 699888..702098 (2211 bp)
Type: Others
Protein ID: WP_171223959.1
Location: 702206..702607 (402 bp)
Type: Others
Protein ID: WP_206044584.1
Location: 702687..702926 (240 bp)
Type: Toxin
Protein ID: WP_171223961.1
Location: 702920..703255 (336 bp)
Type: Antitoxin
Protein ID: WP_171223962.1
Location: 704531..705097 (567 bp)
Type: Others
Protein ID: WP_171223964.1
Location: 705142..706002 (861 bp)
Type: Others
Protein ID: WP_206044585.1
Location: 706323..707528 (1206 bp)
Type: Others
Protein ID: WP_171223965.1
Location: 703271..704290 (1020 bp)
Type: Others
Protein ID: WP_206044695.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HKW67_RS22250697943..699877+1935WP_206044583.1HupE/UreJ family protein-
HKW67_RS02860699888..702098+2211WP_171223959.1PQQ-binding-like beta-propeller repeat protein-
HKW67_RS02865702206..702607+402WP_206044584.1hypothetical protein-
HKW67_RS02870702687..702926+240WP_171223961.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinToxin
HKW67_RS02875702920..703255+336WP_171223962.1type II toxin-antitoxin system PemK/MazF family toxinAntitoxin
HKW67_RS02880703271..704290-1020WP_206044695.1hypothetical protein-
HKW67_RS02885704531..705097+567WP_171223964.1Uma2 family endonuclease-
HKW67_RS02890705142..706002+861WP_206044585.1MBL fold metallo-hydrolase-
HKW67_RS02895706323..707528+1206WP_171223965.1radical SAM protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(7-109)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 8613.79 Da        Isoelectric Point: 4.7558

>T156010 WP_171223961.1 NZ_CP053085:702687-702926 [Gemmatimonas sp. TET16]
MKGKLVRIGNSRGVRLAKPLIEEAGLTDDVEIRVQGGALIITSVESPRAGWAESVTKYGPSKLLDEPSATVFDESEWTW

Download         Length: 240 bp

>T156010 NZ_CP068823:3212597-3212983 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAGGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12111.13 Da        Isoelectric Point: 10.5442

>AT156010 WP_171223962.1 NZ_CP053085:702920-703255 [Gemmatimonas sp. TET16]
MVTAGSVHRGEVYTVELNPTRGREIRKTRPCVIVSPDELNAALGTFIVAPLTTGGHPYPFRVSCRFAGKDGHVVLDQIRT
VDRERIGKRLGVLTAPTQAKILVVLQAMFTA

Download         Length: 336 bp

>AT156010 NZ_CP068823:3212973-3213302 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References