Detailed information of TA system TA156007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2143465..2143997
• Replicon: chromosome
• Accession: NZ_CP053084
• Organism: Limnobacter sp. SAORIC-580

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HKT17_RS10010
• Protein ID: WP_171099770.1
• Coordinates: 2143701..2143997 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HKT17_RS10005
• Protein ID: WP_171099768.1
• Coordinates: 2143465..2143704 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKT17_RS09990	2140034..2142223	+	2190	WP_171099761.1	malate synthase G	-
HKT17_RS09995	2142370..2142840	+	471	WP_171099763.1	C40 family peptidase	-
HKT17_RS10000	2142851..2143390	+	540	WP_171099765.1	hypothetical protein	-
HKT17_RS10005	2143465..2143704	+	240	WP_171099768.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HKT17_RS10010	2143701..2143997	+	297	WP_171099770.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HKT17_RS10015	2144094..2144363	-	270	WP_171099773.1	hypothetical protein	-
HKT17_RS10020	2144360..2144869	-	510	WP_171099775.1	hypothetical protein	-
HKT17_RS10025	2144878..2145213	-	336	WP_171099776.1	hypothetical protein	-
HKT17_RS10030	2145298..2145924	-	627	WP_205882412.1	hypothetical protein	-
HKT17_RS10035	2146154..2146444	-	291	WP_205882413.1	putative addiction module antidote protein	-
HKT17_RS10040	2146812..2147054	-	243	WP_171099780.1	VF530 family protein	-
HKT17_RS10045	2147098..2147694	-	597	WP_171099781.1	hypothetical protein	-
HKT17_RS10050	2147765..2148181	-	417	WP_171099783.1	VOC family protein	-
HKT17_RS10055	2148283..2148849	-	567	WP_171099786.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-93)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11323.15 Da
• Isoelectric Point: 11.1458

>T156007 WP_171099770.1 NZ_CP053084:2143701-2143997 [Limnobacter sp. SAORIC-580]
MTKPFLLTVAARNDLLNIARFTAKRWGNPQRNKYLKQLDDTFRLLARQPEIGIDASGIKPGYRKFVLGSHVIFYRDGSNS
KVVVVRVFHHRMDVDSHL

Nucleotide

• Length: 297 bp

>T156007 NZ_CP068823:c2192733-2192635 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGGCTGGTGGCGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8833.67 Da
• Isoelectric Point: 4.1813

>AT156007 WP_171099768.1 NZ_CP053084:2143465-2143704 [Limnobacter sp. SAORIC-580]
MAKNTSVSLGPHFDQFIASQVQNGRYGSASEVVRAGLRLLEENETQLTQLRRLLEEGEQSGLSDYSYDDLISQLDKEAE

Nucleotide

• Length: 240 bp

>AT156007 NZ_CP068823:2192780-2192846 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT