156005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 7269..7770 Replicon plasmid pHB37-3
Accession NZ_CP053083
Organism Escherichia coli strain HB37

Toxin (Protein)


Gene name TsxA Uniprot ID -
Locus tag HKW69_RS26590 Protein ID WP_023225994.1
Coordinates 7269..7529 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag HKW69_RS26595 Protein ID WP_000931278.1
Coordinates 7519..7770 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKW69_RS26545 2512..2673 + 162 WP_001128311.1 hypothetical protein -
HKW69_RS26550 2867..3028 + 162 WP_001434039.1 type I toxin-antitoxin system Hok family toxin -
HKW69_RS26555 3178..3774 + 597 WP_000125164.1 hypothetical protein -
HKW69_RS26965 3792..4076 - 285 WP_001162371.1 hypothetical protein -
HKW69_RS26565 4150..4815 - 666 WP_000532148.1 P-loop NTPase -
HKW69_RS26570 5412..5741 + 330 WP_000855121.1 hypothetical protein -
HKW69_RS26575 6322..6645 + 324 WP_023225995.1 hypothetical protein -
HKW69_RS26580 6686..6895 + 210 WP_000866037.1 hypothetical protein -
HKW69_RS26585 6993..7217 + 225 WP_000814383.1 hypothetical protein -
HKW69_RS26590 7269..7529 + 261 WP_023225994.1 hypothetical protein Toxin
HKW69_RS26595 7519..7770 + 252 WP_000931278.1 transcriptional regulator Antitoxin
HKW69_RS26600 7682..8038 - 357 Protein_12 hypothetical protein -
HKW69_RS26605 8365..8625 + 261 WP_023225992.1 hypothetical protein -
HKW69_RS26610 8909..9091 - 183 WP_001481829.1 hypothetical protein -
HKW69_RS26615 9649..9831 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
HKW69_RS26620 9856..10293 + 438 WP_023225990.1 type II toxin-antitoxin system HicB family antitoxin -
HKW69_RS26625 10424..10744 - 321 WP_000206710.1 hypothetical protein -
HKW69_RS26630 10755..11018 - 264 WP_023225989.1 hypothetical protein -
HKW69_RS26635 11020..11217 - 198 WP_023225988.1 hypothetical protein -
HKW69_RS26640 11219..11413 - 195 WP_000224733.1 hypothetical protein -
HKW69_RS26645 11394..11867 - 474 WP_023225987.1 hypothetical protein -
HKW69_RS26650 11887..12486 - 600 WP_000091423.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..56716 56716


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9925.43 Da        Isoelectric Point: 10.2412

>T156005 WP_023225994.1 NZ_CP053083:7269-7529 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFNEKAFDTIDFSRDGLRENDKDIVFMMIQEMS
EGKNAK

Download         Length: 261 bp

>T156005 NZ_CP068823:c2072945-2072451 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9420.81 Da        Isoelectric Point: 9.8120

>AT156005 WP_000931278.1 NZ_CP053083:7519-7770 [Escherichia coli]
MLNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp

>AT156005 NZ_CP068823:c2073235-2072942 [Escherichia coli]
ATGGCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References