Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4502388..4503223 Replicon chromosome
Accession NZ_CP053080
Organism Escherichia coli strain HB37

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag HKW69_RS21715 Protein ID WP_001094426.1
Coordinates 4502388..4502765 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag HKW69_RS21720 Protein ID WP_001285575.1
Coordinates 4502855..4503223 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKW69_RS21690 4497894..4498073 + 180 WP_001298063.1 hypothetical protein -
HKW69_RS21695 4498472..4500508 - 2037 WP_000417001.1 hypothetical protein -
HKW69_RS21700 4501457..4501615 - 159 WP_001467148.1 hypothetical protein -
HKW69_RS21705 4501694..4501891 - 198 WP_000839272.1 DUF957 domain-containing protein -
HKW69_RS21710 4501903..4502391 - 489 WP_000761683.1 hypothetical protein -
HKW69_RS21715 4502388..4502765 - 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
HKW69_RS21720 4502855..4503223 - 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HKW69_RS21725 4503303..4503524 - 222 WP_000692350.1 DUF987 domain-containing protein -
HKW69_RS21730 4503611..4504087 - 477 WP_001298074.1 RadC family protein -
HKW69_RS21735 4504102..4504587 - 486 WP_000214415.1 antirestriction protein -
HKW69_RS21740 4504679..4505497 - 819 WP_065377599.1 DUF945 domain-containing protein -
HKW69_RS21745 4505587..4505820 - 234 WP_001278290.1 DUF905 family protein -
HKW69_RS21750 4505826..4506503 - 678 WP_001097301.1 hypothetical protein -
HKW69_RS21755 4506651..4507331 - 681 WP_170172015.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T155992 WP_001094426.1 NZ_CP053080:c4502765-4502388 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T155992 NZ_CP068822:4368331-4368672 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT155992 WP_001285575.1 NZ_CP053080:c4503223-4502855 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT155992 NZ_CP068822:c4368336-4368260 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References