Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3986847..3987682 Replicon chromosome
Accession NZ_CP053080
Organism Escherichia coli strain HB37

Toxin (Protein)


Gene name yeeV Uniprot ID Q83W73
Locus tag HKW69_RS19230 Protein ID WP_000854700.1
Coordinates 3986847..3987224 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag HKW69_RS19235 Protein ID WP_001278232.1
Coordinates 3987314..3987682 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKW69_RS19200 3982170..3982663 + 494 Protein_3758 MarR family transcriptional regulator -
HKW69_RS19205 3983098..3983436 - 339 WP_000772639.1 Arm DNA-binding domain-containing protein -
HKW69_RS19210 3983802..3985121 + 1320 WP_000144686.1 site-specific integrase -
HKW69_RS19215 3985214..3986068 - 855 WP_024174313.1 DUF4942 domain-containing protein -
HKW69_RS19220 3986153..3986350 - 198 WP_000839247.1 DUF957 domain-containing protein -
HKW69_RS19225 3986362..3986850 - 489 WP_000761726.1 hypothetical protein -
HKW69_RS19230 3986847..3987224 - 378 WP_000854700.1 TA system toxin CbtA family protein Toxin
HKW69_RS19235 3987314..3987682 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HKW69_RS19240 3987845..3988066 - 222 WP_000692353.1 DUF987 domain-containing protein -
HKW69_RS19245 3988135..3988611 - 477 WP_001186199.1 RadC family protein -
HKW69_RS19250 3988627..3989112 - 486 WP_000213723.1 antirestriction protein -
HKW69_RS19255 3989204..3990022 - 819 WP_001234709.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE / vat / vat 3943555..4015583 72028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14276.28 Da        Isoelectric Point: 7.8046

>T155983 WP_000854700.1 NZ_CP053080:c3987224-3986847 [Escherichia coli]
MKTLPDTHVREASRCLSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SPCTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T155983 NZ_CP068822:2815958-2816065 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT155983 WP_001278232.1 NZ_CP053080:c3987682-3987314 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT155983 NZ_CP068822:c2815905-2815844 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A1I2

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References