Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1073793..1074591 Replicon chromosome
Accession NZ_CP053080
Organism Escherichia coli strain HB37

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag HKW69_RS05265 Protein ID WP_000854735.1
Coordinates 1073793..1074170 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag HKW69_RS05270 Protein ID WP_032153712.1
Coordinates 1074217..1074591 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKW69_RS05235 1069758..1071023 - 1266 WP_023152178.1 integrase arm-type DNA-binding domain-containing protein -
HKW69_RS05240 1071487..1071813 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HKW69_RS05245 1071810..1072073 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
HKW69_RS05250 1072145..1073011 - 867 WP_032153714.1 DUF4942 domain-containing protein -
HKW69_RS05255 1073096..1073293 - 198 WP_000839265.1 DUF957 domain-containing protein -
HKW69_RS05260 1073305..1073796 - 492 WP_023155722.1 hypothetical protein -
HKW69_RS05265 1073793..1074170 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
HKW69_RS05270 1074217..1074591 - 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HKW69_RS05275 1074671..1074892 - 222 WP_000692345.1 DUF987 domain-containing protein -
HKW69_RS05280 1074961..1075437 - 477 WP_001186715.1 RadC family protein -
HKW69_RS05285 1075453..1075938 - 486 WP_032153711.1 antirestriction protein -
HKW69_RS05290 1076030..1076848 - 819 WP_001234693.1 DUF945 domain-containing protein -
HKW69_RS05295 1076939..1077148 - 210 WP_023155727.1 DUF905 family protein -
HKW69_RS05300 1077178..1077855 - 678 WP_023155728.1 hypothetical protein -
HKW69_RS05305 1077974..1078858 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 papI / papB / papA / papH / papC / papD / papJ / papK / papE / papF / papX / papI / papB 1034943..1123516 88573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T155966 WP_000854735.1 NZ_CP053080:c1074170-1073793 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T155966 NZ_CP068821:4504794-4505051 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT155966 WP_032153712.1 NZ_CP053080:c1074591-1074217 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT155966 NZ_CP068821:4505063-4505614 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References