Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4039876..4040674 Replicon chromosome
Accession NZ_CP053079
Organism Escherichia coli strain K56-43-un

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag HK408_RS19555 Protein ID WP_000854730.1
Coordinates 4040297..4040674 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag HK408_RS19550 Protein ID WP_001285482.1
Coordinates 4039876..4040250 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK408_RS19510 4035845..4036297 + 453 WP_000682723.1 hypothetical protein -
HK408_RS19515 4036415..4036648 + 234 WP_001213775.1 DUF905 family protein -
HK408_RS19520 4036748..4037569 + 822 WP_001234355.1 DUF945 domain-containing protein -
HK408_RS19525 4037569..4037814 + 246 WP_033801903.1 hypothetical protein -
HK408_RS19530 4037908..4038381 + 474 WP_001367563.1 antirestriction protein -
HK408_RS19535 4038397..4038873 + 477 WP_001186752.1 RadC family protein -
HK408_RS19540 4038942..4039163 + 222 WP_000692300.1 DUF987 domain-containing protein -
HK408_RS19545 4039182..4039826 + 645 WP_000086759.1 hypothetical protein -
HK408_RS19550 4039876..4040250 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HK408_RS19555 4040297..4040674 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
HK408_RS19560 4040671..4041163 + 493 Protein_3841 hypothetical protein -
HK408_RS19565 4041242..4042230 - 989 Protein_3842 IS630 family transposase -
HK408_RS19570 4042378..4042566 - 189 Protein_3843 IS66 family transposase -
HK408_RS19575 4042627..4043760 + 1134 WP_000555410.1 IS110-like element ISEc45 family transposase -
HK408_RS19580 4044014..4045418 - 1405 Protein_3845 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T155957 WP_000854730.1 NZ_CP053079:4040297-4040674 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T155957 NZ_CP068821:c2616133-2616026 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT155957 WP_001285482.1 NZ_CP053079:4039876-4040250 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT155957 NZ_CP068821:2616180-2616246 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References