Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1959326..1960157 Replicon chromosome
Accession NZ_CP053079
Organism Escherichia coli strain K56-43-un

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HK408_RS09195 Protein ID WP_000854814.1
Coordinates 1959326..1959700 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag HK408_RS09200 Protein ID WP_001285586.1
Coordinates 1959789..1960157 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK408_RS09155 1954723..1955889 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
HK408_RS09160 1956007..1956480 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
HK408_RS09165 1956678..1957736 + 1059 WP_001200890.1 FUSC family protein -
HK408_RS09170 1957908..1958237 + 330 WP_000450409.1 DUF496 family protein -
HK408_RS09175 1958338..1958520 - 183 WP_001016348.1 hypothetical protein -
HK408_RS09180 1958574..1958720 + 147 Protein_1800 transposase domain-containing protein -
HK408_RS09185 1959009..1959122 - 114 WP_001161660.1 DUF957 domain-containing protein -
HK408_RS09190 1959135..1959329 - 195 WP_000988601.1 hypothetical protein -
HK408_RS09195 1959326..1959700 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HK408_RS09200 1959789..1960157 - 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HK408_RS09205 1960231..1960452 - 222 WP_000692323.1 DUF987 domain-containing protein -
HK408_RS09210 1960521..1960997 - 477 WP_001351157.1 RadC family protein -
HK408_RS09215 1961013..1961486 - 474 WP_000855074.1 antirestriction protein -
HK408_RS09220 1961749..1962570 - 822 WP_001234571.1 DUF945 domain-containing protein -
HK408_RS09225 1962791..1963201 - 411 WP_000846704.1 hypothetical protein -
HK408_RS09230 1963217..1963894 - 678 WP_001362823.1 hypothetical protein -
HK408_RS09235 1964030..1965100 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T155943 WP_000854814.1 NZ_CP053079:c1959700-1959326 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T155943 NZ_CP068821:258436-258543 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT155943 WP_001285586.1 NZ_CP053079:c1960157-1959789 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT155943 NZ_CP068821:c258378-258324 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References