Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 855768..856603 Replicon chromosome
Accession NZ_CP053079
Organism Escherichia coli strain K56-43-un

Toxin (Protein)


Gene name yeeV Uniprot ID A0A377K286
Locus tag HK408_RS04075 Protein ID WP_001519089.1
Coordinates 855768..856145 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A085P7I7
Locus tag HK408_RS04080 Protein ID WP_001327592.1
Coordinates 856235..856603 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK408_RS04050 851841..852824 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
HK408_RS04055 853584..853805 - 222 Protein_796 IS110 family transposase -
HK408_RS04060 854147..854989 - 843 Protein_797 DUF4942 domain-containing protein -
HK408_RS04065 855074..855271 - 198 WP_001519084.1 DUF957 domain-containing protein -
HK408_RS04070 855283..855771 - 489 WP_001519085.1 hypothetical protein -
HK408_RS04075 855768..856145 - 378 WP_001519089.1 TA system toxin CbtA family protein Toxin
HK408_RS04080 856235..856603 - 369 WP_001327592.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HK408_RS04085 856766..856987 - 222 WP_000692323.1 DUF987 domain-containing protein -
HK408_RS04090 857056..857532 - 477 WP_001186727.1 RadC family protein -
HK408_RS04095 857548..858027 - 480 WP_000706981.1 antirestriction protein -
HK408_RS04100 858366..859184 - 819 WP_021524998.1 DUF945 domain-containing protein -
HK408_RS04105 859274..859507 - 234 WP_001278282.1 DUF905 family protein -
HK408_RS04110 859513..860190 - 678 WP_001097301.1 hypothetical protein -
HK408_RS04115 860338..861018 - 681 WP_021524999.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14333.29 Da        Isoelectric Point: 8.2918

>T155938 WP_001519089.1 NZ_CP053079:c856145-855768 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T155938 NZ_CP068820:4321553-4321960 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13901.65 Da        Isoelectric Point: 6.3165

>AT155938 WP_001327592.1 NZ_CP053079:c856603-856235 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT155938 NZ_CP068820:4321306-4321572 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377K286

Antitoxin

Source ID Structure
AlphaFold DB A0A085P7I7

References