155934

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2597986..2598509 Replicon chromosome
Accession NZ_CP053075
Organism Staphylococcus aureus strain SA01

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag HK402_RS13140 Protein ID WP_000074049.1
Coordinates 2597986..2598252 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag HK402_RS13145 Protein ID WP_000587616.1
Coordinates 2598252..2598509 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK402_RS13120 2593293..2594480 - 1188 WP_000026189.1 MFS transporter -
HK402_RS13125 2594876..2595652 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
HK402_RS13130 2595645..2596307 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
HK402_RS13135 2596555..2597631 - 1077 WP_001076673.1 M42 family metallopeptidase -
HK402_RS13140 2597986..2598252 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
HK402_RS13145 2598252..2598509 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HK402_RS13150 2598868..2599323 + 456 WP_000732076.1 DUF1307 domain-containing protein -
HK402_RS13155 2599491..2601068 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
HK402_RS13160 2601263..2602012 + 750 WP_000072462.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T155934 WP_000074049.1 NZ_CP053075:c2598252-2597986 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T155934 NZ_CP068820:3578872-3578979 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT155934 WP_000587616.1 NZ_CP053075:c2598509-2598252 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT155934 NZ_CP068820:c3578823-3578760 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References