Detailed information of TA system TA155928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2223899..2224413
• Replicon: chromosome
• Accession: NZ_CP053075
• Organism: Staphylococcus aureus strain SA01

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: T1YA99
• Locus tag: HK402_RS11210
• Protein ID: WP_000581792.1
• Coordinates: 2223899..2224108 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: HK402_RS11215
• Protein ID: WP_170172394.1
• Coordinates: 2224120..2224413 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK402_RS11190	2219407..2220765	-	1359	WP_000611464.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
HK402_RS11195	2220780..2221850	-	1071	WP_000159631.1	D-alanine--D-alanine ligase	-
HK402_RS11200	2222168..2223370	+	1203	WP_001109939.1	rod shape-determining protein RodA	-
HK402_RS11205	2223634..2223771	-	138	WP_000828354.1	hypothetical protein	-
HK402_RS11210	2223899..2224108	-	210	WP_000581792.1	heavy-metal-associated domain-containing protein	Toxin
HK402_RS11215	2224120..2224413	-	294	WP_170172394.1	copper-sensing transcriptional repressor CsoR	Antitoxin
HK402_RS11220	2224579..2226063	+	1485	WP_000571553.1	cardiolipin synthase	-
HK402_RS11225	2226091..2226738	+	648	WP_001187630.1	HD domain-containing protein	-
HK402_RS11230	2227651..2228523	-	873	WP_000725802.1	membrane protein insertase YidC	-
HK402_RS11235	2228609..2229250	-	642	WP_000483153.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7843.77 Da
• Isoelectric Point: 4.1008

>T155928 WP_000581792.1 NZ_CP053075:c2224108-2223899 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T155928 NZ_CP068820:2774250-2774627 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11206.83 Da
• Isoelectric Point: 6.4782

>AT155928 WP_170172394.1 NZ_CP053075:c2224413-2224120 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEHHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT155928 NZ_CP068820:2773792-2774160 [Escherichia coli]
GTGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• PDB: 6FF1