Detailed information of TA system TA155926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 2123258..2124055
• Replicon: chromosome
• Accession: NZ_CP053075
• Organism: Staphylococcus aureus strain SA01

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HK402_RS10720
• Protein ID: WP_000525014.1
• Coordinates: 2123594..2124055 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: HK402_RS10715
• Protein ID: WP_001260487.1
• Coordinates: 2123258..2123581 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK402_RS10650	2118317..2119075	-	759	WP_001003951.1	DUF1351 domain-containing protein	-
HK402_RS10655	2119086..2119409	-	324	WP_000171560.1	hypothetical protein	-
HK402_RS10660	2119422..2120033	-	612	WP_001105358.1	MBL fold metallo-hydrolase	-
HK402_RS10665	2120056..2120292	-	237	WP_000802314.1	hypothetical protein	-
HK402_RS10670	2120300..2120560	-	261	WP_000291082.1	DUF1108 family protein	-
HK402_RS10675	2120659..2120820	-	162	WP_001285953.1	DUF1270 family protein	-
HK402_RS10680	2120817..2121137	-	321	WP_001120202.1	DUF771 domain-containing protein	-
HK402_RS10685	2121288..2121431	-	144	WP_000939498.1	hypothetical protein	-
HK402_RS10690	2121498..2121720	+	223	Protein_2067	hypothetical protein	-
HK402_RS10695	2121973..2122185	+	213	WP_000362645.1	hypothetical protein	-
HK402_RS10700	2122226..2122375	-	150	WP_000771849.1	hypothetical protein	-
HK402_RS10705	2122390..2122833	-	444	WP_000435352.1	hypothetical protein	-
HK402_RS10710	2122846..2123094	-	249	WP_000272856.1	helix-turn-helix domain-containing protein	-
HK402_RS10715	2123258..2123581	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
HK402_RS10720	2123594..2124055	+	462	WP_000525014.1	hypothetical protein	Toxin
HK402_RS10725	2124072..2124293	+	222	Protein_2074	membrane lipoprotein lipid attachment site-containing protein	-
HK402_RS10730	2124587..2125471	+	885	WP_001025527.1	hypothetical protein	-
HK402_RS10735	2125777..2126145	+	369	Protein_2076	hypothetical protein	-
HK402_RS10740	2126244..2126411	+	168	WP_001166555.1	hypothetical protein	-
HK402_RS10745	2126751..2127455	+	705	Protein_2078	type II toxin-antitoxin system PemK/MazF family toxin	-
HK402_RS10750	2127617..2128654	+	1038	WP_170172385.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2085465..2137734	52269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18104.44 Da
• Isoelectric Point: 4.6915

>T155926 WP_000525014.1 NZ_CP053075:2123594-2124055 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T155926 NZ_CP068820:c2584352-2584062 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT155926 WP_001260487.1 NZ_CP053075:2123258-2123581 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT155926 NZ_CP068820:c2584584-2584342 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36