Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 859384..859861 Replicon chromosome
Accession NZ_CP053075
Organism Staphylococcus aureus strain SA01

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HK402_RS04225 Protein ID WP_000052076.1
Coordinates 859384..859572 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HK402_RS04230 Protein ID WP_001059690.1
Coordinates 859601..859861 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK402_RS04195 855378..855899 + 522 WP_000824481.1 hypothetical protein -
HK402_RS04200 856240..856926 + 687 WP_000141557.1 thermonuclease family protein -
HK402_RS04205 857283..857483 + 201 WP_001059082.1 cold-shock protein -
HK402_RS04210 857975..858193 - 219 WP_000005886.1 hypothetical protein -
HK402_RS04215 858255..858539 - 285 WP_001004399.1 hypothetical protein -
HK402_RS04220 858627..859196 - 570 WP_001106654.1 hypothetical protein -
HK402_RS04225 859384..859572 - 189 WP_000052076.1 hypothetical protein Toxin
HK402_RS04230 859601..859861 - 261 WP_001059690.1 hypothetical protein Antitoxin
HK402_RS04235 860202..860405 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HK402_RS04240 860402..860638 - 237 WP_000349581.1 hypothetical protein -
HK402_RS04245 860863..861444 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
HK402_RS04250 861517..862134 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
HK402_RS04255 862289..862783 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
HK402_RS04260 863182..863604 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
HK402_RS04265 863752..864468 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T155919 WP_000052076.1 NZ_CP053075:c859572-859384 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T155919 NZ_CP068820:1177620-1178114 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT155919 WP_001059690.1 NZ_CP053075:c859861-859601 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT155919 NZ_CP068820:1177330-1177623 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References